Yankees vs Pirates Prediction and MLB Tips - 22 July 2026
Last updated: Jul 21, 2026, 10:21PM | Published: Jul 20, 2026, 6:41PM
The New York Yankees will sqaure off with the Pittsburgh Pirates in MLB action at Yankee Stadium on Wednesday, starting at 9:05am AEST.
Will Warren (7-4, 4.03 ERA) will be on the bump for the Yankees, up against Bubba Chandler (3-8, 4.77 ERA) for the Pirates.
This article features Stats Insider's prediction and tips for the Yankees vs Pirates game, plus the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the result of Wednesday's NY Yankees vs Pittsburgh MLB match-up 10,000 times.
Our independent predictive analytics model gives the Yankees a 58% chance of beating the Pirates at Yankee Stadium.
Yankees vs Pirates: Odds
The latest betting odds in Australia for Wednesday's MLB game at Yankee Stadium are shown below:
- Head to Head: Yankees $1.77, Pirates $2.10
- Line: Yankees -1.5 ($2.50), Pirates +1.5 ($1.56)
- Total (Over/Under 9.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Yankees at $1.77 and the Pirates at $2.10.
The Yankees are listed as 1.5-run favourites against the Pirates, with odds of $2.50 available at TAB.
For the underdog Pirates (+1.5) to cover the line, TAB offers odds of $1.56.
The over/under for total runs scored is set at 9.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Pirates (+1.5) are predicted to cover the line 58% of the time, while the 9.5-run over/under is expected to go over 51% of the time.
Yankees vs Pirates: Best Bets
- Head to Head: NY Yankees at $1.77 with TAB
- Line: Yankees -1.5 at $2.50 with TAB
- Total Runs: Over 9.5 at $1.91 with TAB
Today's Yankees vs Pirates betting tips are based on detailed simulations and gambling expertise to help you place more informed bets with your chosen online bookie.
Even though the Pirates are more likely to cover the line, our best bet of Yankees -1.5 is based on the likelihood of that happening, as projected by our predictive analytics model, and the best odds available.
Yankees vs Pirates: Prediction
Stats Insider provides full coverage of the NY Yankees vs Pittsburgh game on Wednesday, including data-driven predictions and top betting tips.
Our model updates frequently, so keep checking this article for the latest betting tips before the NY Yankees vs Pittsburgh game.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, plus predictions for a wide range of other sports.
Yankees vs Pirates: Essential Details
The game between the Yankees and Pirates at Yankee Stadium is scheduled to start at 9:05am AEST on Wednesday.
- Teams: New York Yankees vs Pittsburgh Pirates
- Date: Wednesday 22 July 2026
- Time: 9:05am AEST
- Venue: Yankee Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our NY Yankees vs Pittsburgh predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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