White Sox vs Padres Prediction and MLB Tips - 22 September 2025
Last updated: Sep 21, 2025, 6:10PM | Published: Sep 20, 2025, 9:29PM
The Chicago White Sox will take on the San Diego Padres in Game of the League Series at Rate Field on Monday, starting at 4:10am AEST.
The White Sox will have Sean Burke (4-10, 4.29 ERA) start, while the Padres are going with Michael King (4-3, 3.84 ERA).
This article features Stats Insider's top betting tips for the White Sox vs Padres game, plus the latest betting odds in Australia.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Monday's White Sox vs San Diego MLB game 10,000 times.
Our leading predictive analytics model currently gives the Padres a 62% chance of beating the White Sox at Rate Field.
White Sox vs Padres: Odds
The current betting odds in Australia for Monday's MLB game at Rate Field are listed here:
- Head to Head: White Sox $2.50, Padres $1.56
- Line: White Sox +1.5 ($1.87), Padres -1.5 ($1.95)
- Total (Over/Under 8.167 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the White Sox at $2.50 and the Padres at $1.56.
The White Sox are 1.5-run underdogs against the Padres, with odds of $1.87 available at TAB.
For the favourite Padres (-1.5) to cover the line, TAB offers odds of $1.95.
The over/under for total runs scored is set at 8.167 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the White Sox (+1.5) are predicted to cover the line 51% of the time, while the 8.167-run over/under is expected to go over 54% of the time.
White Sox vs Padres: Best Bets
- Head to Head: San Diego at $1.56 with TAB
- Line: Padres -1.5 at $1.95 with TAB
- Total Runs: Over 8.167 at $1.91 with TAB
Stats Insider's White Sox vs Padres betting tips are based on world-class simulations and gambling experience to help you place more informed bets with your chosen online bookie.
Although the White Sox are more likely to cover the line, our best bet of Padres -1.5 is based on the likelihood of that happening, as suggested by our predictive analytics model, and the top odds available.
White Sox vs Padres: Prediction
Stats Insider provides full betting coverage of the White Sox vs San Diego game on Monday, including data-driven predictions and free tips.
Remember, our model updates frequently, so keep checking this page for the latest betting analysis before the White Sox vs San Diego game.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
White Sox vs Padres: Essential Details
The match-up between the White Sox and Padres at Rate Field is scheduled to begin at 4:10am AEST on Monday.
- Teams: Chicago White Sox vs San Diego Padres
- Date: Monday 22 September 2025
- Time: 4:10am AEST
- Venue: Rate Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our White Sox vs San Diego predictions have been made based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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