White Sox vs Mariners Prediction and MLB Tips - 21 May 2025

The Chicago White Sox will sqaure off with the Seattle Mariners in MLB action at Rate Field on Wednesday, commencing at 9:40am AEST.

Adrian Houser (0-0, 0.00 ERA) will be on the bump for the White Sox, up against Casey Legumina (3-1, 1.84 ERA) for the Mariners.

This article features Stats Insider's prediction and tips for the White Sox vs Mariners game, plus the latest betting odds in Australia.

Who Will Win?

Using advanced computer power and data, Stats Insider has simulated the result of Wednesday's White Sox vs Seattle MLB match-up 10,000 times.

Our independent predictive analytics model gives the Mariners a 58% chance of beating the White Sox at Rate Field.

White Sox vs Mariners: Odds

The current betting odds in Australia for Wednesday's MLB game at Rate Field are listed here:

• Head to Head: White Sox $2.50, Mariners $1.56
• Line: White Sox +1.5 ($1.93), Mariners -1.5 ($1.90)
• Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the White Sox at $2.50 and the Mariners at $1.56.

The White Sox are listed as 1.5-run underdogs against the Mariners, with odds of $1.93 available at TAB.

For the favourite Mariners (-1.5) to cover the line, TAB offers odds of $1.90.

The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the White Sox (+1.5) are predicted to cover the line 54% of the time, while the 8.5-run over/under is expected to stay under 54% of the time.

White Sox vs Mariners: Best Bets

• Head to Head: White Sox at $2.50 with TAB
• Line: White Sox +1.5 at $1.93 with TAB
• Total Runs: Under 8.5 at $1.91 with TAB

If you see a 🔥, that means it's one of Stats Insider's best tips for today across any sport.

Stats Insider's White Sox vs Mariners best bets are based on complex simulations and betting experience to help you place smarter bets with your chosen online bookie.

While the Mariners have a higher chance of winning the game, betting on the White Sox to win is our preferred option because of the 3.3% edge found when comparing our data-led probabilities to the odds currently on offer.

Making use of the edges seen here at Stats Insider is one of the keys to being profitable in the long run.

White Sox vs Mariners: Prediction

Stats Insider provides full betting coverage of the White Sox vs Seattle game on Wednesday, including data-driven predictions and expert tips.

Remember, our model updates frequently, so bookmark this page for the latest betting tips before the White Sox vs Seattle game.

As always, see Stats Insider's Best Bets for betting tips for every MLB game, plus predictions for a wide range of other sports.

White Sox vs Mariners: Essential Details

The match-up between the White Sox and Mariners at Rate Field is scheduled to begin at 9:40am AEST on Wednesday.

• Teams: Chicago White Sox vs Seattle Mariners
• Date: Wednesday 21 May 2025
• Time: 9:40am AEST
• Venue: Rate Field

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our White Sox vs Seattle predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.

If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures probabilities for the MLB.