Twins vs Guardians Prediction and MLB Tips - 22 September 2025
Last updated: Sep 21, 2025, 6:10PM | Published: Sep 20, 2025, 9:29PM
The Minnesota Twins will face the Cleveland Guardians in Game of the League Series at Target Field on Monday, starting at 4:10am AEST.
The Twins will send Simeon Woods Richardson (7-4, 4.31 ERA) to the mound, pitting him against Joey Cantillo (5-3, 3.27 ERA) for the Guardians.
This article features Stats Insider's free betting tips for the Twins vs Guardians game, along with the latest betting odds in Australia.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Monday's Minnesota vs Cleveland MLB game 10,000 times.
Our leading predictive analytics model gives the Guardians a 55% chance of beating the Twins at Target Field.
Twins vs Guardians: Odds
The current betting odds in Australia for Monday's MLB game at Target Field are shown here:
- Head to Head: Twins $2.20, Guardians $1.71
- Line: Twins +1.5 ($1.74), Guardians -1.5 ($2.14)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Twins at $2.20 and the Guardians at $1.71.
The Twins are 1.5-run underdogs against the Guardians, with odds of $1.74 available at TAB.
For the favourite Guardians (-1.5) to cover the line, TAB offers odds of $2.14.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Twins (+1.5) are predicted to cover the line 58% of the time, while the 8.5-run over/under is expected to go over 52% of the time.
Twins vs Guardians: Best Bets
- Head to Head: Minnesota at $2.20 with TAB
- Line: Twins +1.5 at $1.74 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
These Twins vs Guardians betting tips are based on market-leading modelling and betting expertise to help you place better bets with your chosen online bookie.
While the Guardians have a higher chance of winning the game, betting on the Twins to win is our preferred option due to the 1.4% edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is crucial to achieving long-term profitability.
Twins vs Guardians: Prediction
Stats Insider provides full betting coverage of the Minnesota vs Cleveland game on Monday, including data-driven predictions and the best betting tips.
Our model updates frequently, so refresh this page for the latest betting tips before the Minnesota vs Cleveland game.
As always, see Stats Insider's Best Bets to get the best tips for every MLB game, as well as predictions for a wide range of other sports.
Twins vs Guardians: Essential Details
The game between the Twins and Guardians at Target Field is scheduled to begin at 4:10am AEST on Monday.
- Teams: Minnesota Twins vs Cleveland Guardians
- Date: Monday 22 September 2025
- Time: 4:10am AEST
- Venue: Target Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Minnesota vs Cleveland predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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