Twins vs Guardians Prediction and MLB Tips - 22 May 2025
Last updated: May 21, 2025, 5:09PM | Published: May 20, 2025, 6:30PM
The Minnesota Twins will sqaure off with the Cleveland Guardians in MLB action at Target Field on Thursday, commencing at 3:10am AEST.
Joe Ryan (4-2, 2.42 ERA) will start for the Twins, while the Guardians are going with Tanner Bibee (3-4, 4.06 ERA).
This article features Stats Insider's prediction and tips for the Twins vs Guardians game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Thursday's Minnesota vs Cleveland MLB game 10,000 times.
Our leading predictive analytics model currently gives the Twins a 57% chance of beating the Guardians at Target Field.
Twins vs Guardians: Odds
The latest betting odds in Australia for Thursday's MLB game at Target Field are listed below:
- Head to Head: Twins $1.67, Guardians $2.26
- Line: Twins -1.5 ($2.45), Guardians +1.5 ($1.57)
- Total (Over/Under 7.333 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Twins at $1.67 and the Guardians at $2.26.
The Twins are listed as 1.5-run favourites against the Guardians, with odds of $2.45 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.57.
The over/under for total runs scored is set at 7.333 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Guardians (+1.5) are predicted to cover the line 62% of the time, while the 7.333-run over/under is expected to is considered an equal 50-50 chance of hitting.
Twins vs Guardians: Best Bets
- Head to Head: Cleveland at $2.26 with TAB
- Line: Guardians +1.5 at $1.57 with TAB
- Total Runs: Over 7.333 at $1.91 with TAB
These Twins vs Guardians best bets are based on market-leading modelling and wagering expertise to help you place better bets with your chosen online bookie.
While the Twins have a higher chance of winning the game, betting on the Guardians to win is our preferred option because of the edge identified when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges published on Stats Insider is crucial to being a profitable sports bettor in the long run.
Twins vs Guardians: Prediction
Stats Insider provides full betting coverage of the Minnesota vs Cleveland game on Thursday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so refresh this article for the latest betting analysis before the Minnesota vs Cleveland match-up.
As always, see Stats Insider's Best Bets to get the best tips for every MLB game, as well as predictions for a wide range of other sports.
Twins vs Guardians: Essential Details
The match-up between the Twins and Guardians at Target Field is scheduled to start at 3:10am AEST on Thursday.
- Teams: Minnesota Twins vs Cleveland Guardians
- Date: Thursday 22 May 2025
- Time: 3:10am AEST
- Venue: Target Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Minnesota vs Cleveland predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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