Twins vs Guardians Prediction and MLB Tips - 21 May 2025
Last updated: May 20, 2025, 9:21PM | Published: May 19, 2025, 6:29PM
The Minnesota Twins will face the Cleveland Guardians in MLB action at Target Field on Wednesday, starting at 9:40am AEST.
Chris Paddack (2-3, 4.05 ERA) will start for the Twins, while the Guardians will counter with Gavin Williams (3-2, 4.29 ERA).
This article features Stats Insider's free betting tips for the Twins vs Guardians game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Minnesota vs Cleveland MLB match-up 10,000 times.
Our proven predictive analytics model currently gives the Twins a 51% chance of beating the Guardians at Target Field.
Twins vs Guardians: Odds
The current betting odds in Australia for Wednesday's MLB game at Target Field are listed here:
- Head to Head: Twins $1.87, Guardians $1.95
- Line: Twins -1.5 ($2.85), Guardians +1.5 ($1.44)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Twins at $1.87 and the Guardians at $1.95.
The Twins are listed as 1.5-run favourites against the Guardians, with odds of $2.85 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.44.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Guardians (+1.5) are predicted to cover the line 67% of the time, while the 7-run over/under is expected to go over 53% of the time.
Twins vs Guardians: Best Bets
- Head to Head: Cleveland at $1.95 with TAB
- Line: Guardians +1.5 at $1.44 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Stats Insider's Twins vs Guardians betting tips are based on market-leading simulations and betting intelligence to bring you the best possible advice around the clock.
While the Twins have a higher chance of winning the game, betting on the Guardians to win is our recommended option due to the edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published on Stats Insider is one of the keys to being a profitable punter in the long run.
Twins vs Guardians: Prediction
Stats Insider provides full coverage of the Minnesota vs Cleveland game on Wednesday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so keep checking this page for the latest betting tips before the Minnesota vs Cleveland game.
As always, see Stats Insider's Best Bets to get betting tips for every MLB game, as well as predictions for a wide range of other sports.
Twins vs Guardians: Essential Details
The game between the Twins and Guardians at Target Field is scheduled to begin at 9:40am AEST on Wednesday.
- Teams: Minnesota Twins vs Cleveland Guardians
- Date: Wednesday 21 May 2025
- Time: 9:40am AEST
- Venue: Target Field
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Minnesota vs Cleveland predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures odds for the MLB.
