Titans vs Colts Prediction and Preview - NFL Week 3, 2025

The Tennessee Titans will sqaure off with the Indianapolis Colts in NFL Week 3 action at Nissan Stadium on Monday, September 22, starting at 3:00am AEST.

This article features Stats Insider's prediction and tips for the Titans vs Colts game, plus the latest betting odds in Australia.

Who Will Win?

Utilising advanced computer power and data, Stats Insider has simulated the outcome of Colts vs Titans 10,000 times.

Our proven predictive analytics model gives the Titans a 55% chance of winning against the Colts at Nissan Stadium.

Titans vs Colts: Odds

The latest Bet365 betting odds in Australia for this NFL game at Nissan Stadium are listed below:

• Head to Head: Titans $2.20, Colts $1.71
• Line: Titans +2.5 ($1.91), Colts -2.5 ($1.91)
• Total (Over/Under 42.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Titans at $2.20 and the Colts at $1.71.

The Titans are 2.5-point underdogs against the Colts, with odds of $1.91 available at Bet365.

For the favourite Colts (-2.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Titans (+2.5) are predicted to cover the line 62% of the time, while the 42.5-point over/under is expected to go over 56% of the time.

Titans vs Colts: Best Bets

• Head to Head: Tennessee at $2.20 with Bet365
• Line: Titans +2.5 at $1.91 with Bet365
• Total Points: Over 42.5 at $1.91 with Bet365

If you see a 🔥, that means you've found one of our best tips of the day across all sports.

Today's Titans vs Colts betting tips are based on complex modelling and betting experience to give you the best possible advice every time.

Titans vs Colts: Prediction

Stats Insider's predicted final score for Titans vs Colts at Nissan Stadium in Week 3 is the Titans winning 23-21.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the Tennessee vs Indianapolis game in Week 3, including data-driven predictions and expert tips.

Our model updates regularly, so refresh this article for the latest betting analysis before the Tennessee vs Indianapolis game.

As always, see Stats Insider's Best Bets to get betting tips on every NFL game, as well as predictions for a wide range of other sports.

Titans vs Colts: Week 3 Essential Details

The NFL Week 3 game between the Titans and Colts at Nissan Stadium is scheduled to start at 3:00am AEST on Monday, September 22.

• Teams: Tennessee Titans vs Indianapolis Colts
• Date: Monday 22 September 2025
• Time: 3:00am AEST
• Venue: Nissan Stadium

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Tennessee vs Indianapolis predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you decide to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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