Titans vs Colts Prediction and Preview - NFL Week 3, 2025

The Tennessee Titans will sqaure off with the favoured Indianapolis Colts in NFL Week 3 action at Nissan Stadium on Monday, starting at 3:00am AEST.

This article features Stats Insider's top betting tips for the Titans vs Colts game, along with the latest betting odds and touchdown scorer tips.

Who Will Win?

Using advanced machine learning and data, Stats Insider has simulated the result of Monday's Tennessee vs Indianapolis NFL game 10,000 times.

Our leading predictive analytics model gives the Colts a 70% chance of beating the Titans in Week 3 of the NFL season.

Titans vs Colts: Odds

The current Bet365 betting odds in Australia for Monday's NFL game at Nissan Stadium are listed below:

• Head to Head: Titans $3.10, Colts $1.38
• Line: Titans +6 ($1.91), Colts -6 ($1.91)
• Total (Over/Under 42.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Titans at $3.10 and the Colts at $1.38.

The Titans are listed as 6-point underdogs against the Colts, with odds of $1.91 available at Bet365.

For the favourite Colts (-6) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Titans (+6) are predicted to cover the line 53% of the time, while the 42.5-point over/under is expected to go over 54% of the time.

Titans vs Colts: Best Bets

• Head to Head: Indianapolis at $1.38 with Bet365
• Line: Titans +6 at $1.91 with Bet365
• Total Points: Over 42.5 at $1.91 with Bet365

Today's Titans vs Colts betting tips are based on detailed modelling and wagering experience to help you place smarter bets with your chosen online bookie.

Titans vs Colts: Prediction

Stats Insider's predicted final score for Titans vs Colts at Nissan Stadium in Week 3 is the Colts winning 24-19.

This prediction is based on each team's average score following 10,000 game simulations.

Stats Insider provides full coverage of the Tennessee vs Indianapolis game in Week 3, including data-driven predictions and top betting tips.

Get expert analysis from the US with Dimers' in-depth Titans vs Colts prediction.

18+. Odds correct at time of publishing and subject to change.

Titans vs Colts: TD Scorer Tips

Who will score an anytime touchdown in Titans vs Colts? The latest data is in.

According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first touchdown in Titans vs Colts.

Taylor has a 17.5% chance of scoring the first TD at Nissan Stadium, while the Colts RB has a 57.4% chance of registering an anytime touchdown.

Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.

First Touchdown Scorer Tips

Titans First TD Tips

• Tony Pollard: 11.5% probability
• Calvin Ridley: 7.2% probability
• Elic Ayomanor: 5.7% probability
• Chig Okonkwo: 4.4% probability
• Tyler Lockett: 2.6% probability

Colts First TD Tips

• Jonathan Taylor: 17.5% probability
• Daniel Jones: 7.1% probability
• Tyler Warren: 5.8% probability
• Michael Pittman: 5.2% probability
• Josh Downs: 4.6% probability

Anytime Touchdown Scorer Tips

Titans Anytime TD Tips

• Tony Pollard: 40.6% probability
• Calvin Ridley: 27.8% probability
• Elic Ayomanor: 22.6% probability
• Chig Okonkwo: 17.9% probability
• Tyler Lockett: 11.2% probability

Colts Anytime TD Tips

• Jonathan Taylor: 57.4% probability
• Daniel Jones: 29.2% probability
• Tyler Warren: 24.5% probability
• Michael Pittman: 22.4% probability
• Josh Downs: 20.1% probability

Titans-Colts Projected Player Stats

Of the starting quarterbacks, the Titans' Cam Ward is projected for 202 passing yards. The Colts' Daniel Jones is expected to throw for 219 yards.

Titans Starting QB

• Cam Ward: 202 projected passing yards

Colts Starting QB

• Daniel Jones: 219 projected passing yards

Titans Rushing Yards

• Tony Pollard: 75 projected yards
• Julius Chestnut: 13 projected yards
• Cam Ward: 12 projected yards

Colts Rushing Yards

• Jonathan Taylor: 91 projected yards
• Daniel Jones: 25 projected yards
• DJ Giddens: 12 projected yards

Titans Receiving Yards

• Calvin Ridley: 56 projected yards
• Elic Ayomanor: 43 projected yards
• Chig Okonkwo: 35 projected yards
• Tyler Lockett: 18 projected yards
• Chimere Dike: 18 projected yards

Colts Receiving Yards

• Michael Pittman: 52 projected yards
• Tyler Warren: 49 projected yards
• Josh Downs: 46 projected yards
• Alec Pierce: 34 projected yards
• Jonathan Taylor: 17 projected yards

Our model updates frequently, so bookmark this article for the latest betting predictions before the Tennessee vs Indianapolis match-up.

As always, see Stats Insider's Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.

Titans vs Colts: Week 3 Essential Details

The NFL Week 3 game between the Titans and Colts at Nissan Stadium is scheduled to begin at 3:00am AEST on Monday.

• Teams: Tennessee Titans vs Indianapolis Colts
• Date: Monday 22 September 2025
• Time: 3:00am AEST
• Venue: Nissan Stadium

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our Tennessee vs Indianapolis predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.

If you choose to use our NFL predictions for betting purposes, it's crucial to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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