Titans vs Chiefs Prediction and Preview - NFL Week 16, 2025

The Tennessee Titans will face the favoured Kansas City Chiefs in NFL Week 16 action at Nissan Stadium on Monday, December 22, starting at 5:00am AEDT.

This article features Stats Insider's prediction and tips for the Titans vs Chiefs game, as well as the latest betting odds in Australia.

Who Will Win?

Based on advanced computer power and data, Stats Insider has simulated the outcome of Chiefs vs Titans 10,000 times.

Our leading predictive analytics model gives the Chiefs an 86% chance of winning against the Titans at Nissan Stadium.

Titans vs Chiefs: Odds

The current Bet365 betting odds in Australia for this NFL game at Nissan Stadium are shown here:

• Head to Head: Titans $5.75, Chiefs $1.15
• Line: Titans +10.5 ($1.91), Chiefs -10.5 ($1.91)
• Total (Over/Under 41 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Titans at $5.75 and the Chiefs at $1.15.

The Titans are listed as 10.5-point underdogs against the Chiefs, with odds of $1.91 available at Bet365.

For the favourite Chiefs (-10.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 41 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Chiefs (-10.5) are predicted to cover the line 51% of the time, while the 41-point over/under is expected to go over 52% of the time.

Titans vs Chiefs: Best Bets

• Head to Head: Kansas City at $1.15 with Bet365
• Line: Chiefs -10.5 at $1.91 with Bet365
• Total Points: Over 41 at $1.91 with Bet365

These Titans vs Chiefs best bets are based on detailed modelling and wagering expertise to provide you with the best possible advice around the clock.

Titans vs Chiefs: Prediction

Stats Insider's predicted final score for Titans vs Chiefs at Nissan Stadium in Week 16 is the Chiefs winning 25-15.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the Tennessee vs Kansas City game in Week 16, including data-driven predictions and live updatestips.

Our model updates regularly, so bookmark this article for the latest betting predictions before the Tennessee vs Kansas City match-up.

As always, see Stats Insider's Best Bets for betting tips for every NFL game, plus predictions for a wide range of other sports.

Titans vs Chiefs: Week 16 Essential Details

The NFL Week 16 match-up between the Titans and Chiefs at Nissan Stadium is scheduled to start at 5:00am AEDT on Monday, December 22.

• Teams: Tennessee Titans vs Kansas City Chiefs
• Date: Monday 22 December 2025
• Time: 5:00am AEDT
• Venue: Nissan Stadium

All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.

Conclusion

Our Tennessee vs Kansas City predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.

If you choose to use our predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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