Tigers vs Guardians Prediction and MLB Tips - 19 September 2025
Last updated: Sep 18, 2025, 5:10PM | Published: Sep 17, 2025, 7:30PM
The Detroit Tigers will sqaure off with the Cleveland Guardians in MLB action at Comerica Park on Friday, commencing at 3:10am AEST.
The Tigers will have Tarik Skubal (13-5, 2.26 ERA) start, up against Tanner Bibee (10-11, 4.44 ERA) for the Guardians.
This article features Stats Insider's top betting tips for the Tigers vs Guardians game, along with the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the result of Friday's Detroit vs Cleveland MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Tigers a 69% chance of defeating the Guardians at Comerica Park.
Tigers vs Guardians: Odds
The latest betting odds in Australia for Friday's MLB game at Comerica Park are listed here:
- Head to Head: Tigers $1.41, Guardians $2.95
- Line: Tigers -1.5 ($1.92), Guardians +1.5 ($1.88)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Tigers at $1.41 and the Guardians at $2.95.
The Tigers are listed as 1.5-run favourites against the Guardians, with odds of $1.92 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.88.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 51% of the time, while the 7.5-run over/under is expected to stay under 53% of the time.
Tigers vs Guardians: Best Bets
- Head to Head: Detroit at $1.41 with TAB
- Line: Guardians +1.5 at $1.88 with TAB
- Total Runs: Under 7.5 at $1.91 with TAB
These Tigers vs Guardians predictions are based on detailed simulations and gambling intelligence to provide you with the best possible advice around the clock.
Tigers vs Guardians: Prediction
Stats Insider provides full coverage of the Detroit vs Cleveland game on Friday, including data-driven predictions and the best betting tips.
Our model updates regularly, so refresh this article for the latest betting predictions before the Detroit vs Cleveland game.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, plus predictions for a wide range of other sports.
Tigers vs Guardians: Essential Details
The game between the Tigers and Guardians at Comerica Park is scheduled to start at 3:10am AEST on Friday.
- Teams: Detroit Tigers vs Cleveland Guardians
- Date: Friday 19 September 2025
- Time: 3:10am AEST
- Venue: Comerica Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Detroit vs Cleveland predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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