Tigers vs Guardians Prediction and MLB Tips - 18 September 2025
Last updated: Sep 17, 2025, 10:41PM | Published: Sep 16, 2025, 7:30PM
The Detroit Tigers will face the Cleveland Guardians in MLB action at Comerica Park on Thursday, commencing at 8:40am AEST.
Jack Flaherty (8-13, 4.69 ERA) will start for the Tigers, pitting him against Gavin Williams (10-5, 3.16 ERA) for the Guardians.
This article features Stats Insider's prediction and tips for the Tigers vs Guardians game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Thursday's Detroit vs Cleveland MLB match-up 10,000 times.
Our leading predictive analytics model gives the Tigers a 58% chance of winning against the Guardians at Comerica Park.
Tigers vs Guardians: Odds
The latest betting odds in Australia for Thursday's MLB game at Comerica Park are listed here:
- Head to Head: Tigers $1.71, Guardians $2.20
- Line: Tigers -1.5 ($2.45), Guardians +1.5 ($1.59)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Tigers at $1.71 and the Guardians at $2.20.
The Tigers are listed as 1.5-run favourites against the Guardians, with odds of $2.45 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.59.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 61% of the time, while the 8-run over/under is expected to go over 51% of the time.
Tigers vs Guardians: Best Bets
- Head to Head: Detroit at $1.71 with TAB
- Line: Guardians +1.5 at $1.59 with TAB
- Total Runs: Over 8 at $1.91 with TAB
These Tigers vs Guardians betting tips are based on detailed modelling and betting expertise to help you place smarter bets with your chosen online bookie.
Tigers vs Guardians: Prediction
Stats Insider provides full coverage of the Detroit vs Cleveland game on Thursday, including data-driven predictions and the best betting tips.
Remember, our model updates frequently, so refresh this page for the latest betting tips before the Detroit vs Cleveland match-up.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Tigers vs Guardians: Essential Details
The match-up between the Tigers and Guardians at Comerica Park is scheduled to begin at 8:40am AEST on Thursday.
- Teams: Detroit Tigers vs Cleveland Guardians
- Date: Thursday 18 September 2025
- Time: 8:40am AEST
- Venue: Comerica Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Detroit vs Cleveland predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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