Tigers vs Guardians Prediction and MLB Tips - 17 September 2025

The Detroit Tigers will face the Cleveland Guardians in MLB action at Comerica Park on Wednesday, commencing at 8:40am AEST.

Casey Mize (14-5, 3.83 ERA) will start on the mound for the Tigers, while the Guardians are going with Joey Cantillo (5-3, 3.36 ERA).

This article features Stats Insider's free betting tips for the Tigers vs Guardians game, plus the latest betting odds in Australia.

Who Will Win?

Using trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Detroit vs Cleveland MLB game 10,000 times.

Our leading predictive analytics model gives the Tigers a 55% chance of winning against the Guardians at Comerica Park.

Tigers vs Guardians: Odds

The current betting odds in Australia for Wednesday's MLB game at Comerica Park are listed below:

• Head to Head: Tigers $1.71, Guardians $2.20
• Line: Tigers -1.5 ($2.45), Guardians +1.5 ($1.59)
• Total (Over/Under 8 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Tigers at $1.71 and the Guardians at $2.20.

The Tigers are 1.5-run favourites against the Guardians, with odds of $2.45 available at TAB.

For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.59.

The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 63% of the time, while the 8-run over/under is expected to go over 51% of the time.

Tigers vs Guardians: Best Bets

• Head to Head: Cleveland at $2.20 with TAB
• Line: Guardians +1.5 at $1.59 with TAB
• Total Runs: Over 8 at $1.91 with TAB

Our Tigers vs Guardians betting tips are based on complex modelling and betting experience to help you place smarter bets with your chosen online bookie.

While the Tigers have a higher chance of winning the game, betting on the Guardians to win is our preferred option due to the 1.6% edge identified when comparing our data-driven probabilities to the odds currently available.

Taking advantage of the edges published here at Stats Insider is crucial to being profitable in the long run.

Tigers vs Guardians: Prediction

Stats Insider provides full betting coverage of the Detroit vs Cleveland game on Wednesday, including data-driven predictions and free betting tips.

Remember, our model updates regularly, so keep checking this article for the latest betting predictions before the Detroit vs Cleveland game.

As always, see our Best Bets for the best tips on every MLB game, plus predictions for a wide range of other sports.

Tigers vs Guardians: Essential Details

The match-up between the Tigers and Guardians at Comerica Park is scheduled to begin at 8:40am AEST on Wednesday.

• Teams: Detroit Tigers vs Cleveland Guardians
• Date: Wednesday 17 September 2025
• Time: 8:40am AEST
• Venue: Comerica Park

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Detroit vs Cleveland predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.

If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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