Tigers vs Guardians Prediction and MLB Tips - 17 September 2025

The Detroit Tigers will take on the Cleveland Guardians in MLB action at Comerica Park on Wednesday, beginning at 8:40am AEST.

Casey Mize (14-5, 3.83 ERA) will start for the Tigers, while the Guardians will counter with Joey Cantillo (5-3, 3.36 ERA).

This article features Stats Insider's prediction and tips for the Tigers vs Guardians game, along with the latest betting odds in Australia.

Who Will Win?

Utilising advanced computer power and data, Stats Insider has simulated the outcome of Wednesday's Detroit vs Cleveland MLB match-up 10,000 times.

Our leading predictive analytics model currently gives the Tigers a 56% chance of winning against the Guardians at Comerica Park.

Tigers vs Guardians: Odds

The latest betting odds in Australia for Wednesday's MLB game at Comerica Park are shown below:

• Head to Head: Tigers $1.71, Guardians $2.20
• Line: Tigers -1.5 ($2.45), Guardians +1.5 ($1.59)
• Total (Over/Under 8 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Tigers at $1.71 and the Guardians at $2.20.

The Tigers are 1.5-run favourites against the Guardians, with odds of $2.45 available at TAB.

For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.59.

The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Guardians (+1.5) are predicted to cover the line 62% of the time, while the 8-run over/under is expected to is considered an equal 50-50 chance of hitting.

Tigers vs Guardians: Betting Tips

• Head to Head: Detroit at $1.71 with TAB
• Line: Guardians +1.5 at $1.59 with TAB
• Total Runs: Under 8 at $1.91 with TAB

Today's Tigers vs Guardians predictions are based on complex simulations and wagering expertise to give you the best possible advice around the clock.

Tigers vs Guardians: Prediction

Stats Insider provides full coverage of the Detroit vs Cleveland game on Wednesday, including data-driven predictions and expert tips.

Our model updates frequently, so keep checking this page for the latest betting analysis before the Detroit vs Cleveland game.

As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.

Tigers vs Guardians: Essential Details

The game between the Tigers and Guardians at Comerica Park is scheduled to commence at 8:40am AEST on Wednesday.

• Teams: Detroit Tigers vs Cleveland Guardians
• Date: Wednesday 17 September 2025
• Time: 8:40am AEST
• Venue: Comerica Park

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our Detroit vs Cleveland predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.

If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures probabilities for the MLB.