Texans vs Bills Prediction and Preview - NFL Week 12, 2025
Last updated: Nov 20, 2025, 8:44AM | Published: Nov 14, 2025, 5:11AM
The Houston Texans will face the favoured Buffalo Bills in NFL Week 12 action at NRG Stadium on Friday, starting at 12:15pm AEDT.
This article features Stats Insider's prediction and tips for the Texans vs Bills game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Friday's Houston vs Buffalo NFL match-up 10,000 times.
Our proven predictive analytics model gives the Bills a 68% chance of winning against the Texans in Week 12 of the NFL season.
Texans vs Bills: Odds
The latest Bet365 betting odds in Australia for Friday's NFL game at NRG Stadium are listed here:
- Head to Head: Texans $3.35, Bills $1.34
- Line: Texans +6 ($1.91), Bills -6 ($1.91)
- Total (Over/Under 43.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Texans at $3.35 and the Bills at $1.34.
The Texans are listed as 6-point underdogs against the Bills, with odds of $1.91 available at Bet365.
For the favourite Bills (-6) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Texans (+6) are predicted to cover the line 57% of the time, while the 43.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Texans vs Bills: Best Bets
- Head to Head: Houston at $3.35 with Bet365
- Line: Texans +6 at $1.91 with Bet365
- Total Points: Under 43.5 at $1.91 with Bet365
When you see a 🔥, that means you've found one of Stats Insider's best bets for today across all sports.
Today's Texans vs Bills predictions are based on market-leading simulations and wagering experience to bring you the best possible advice 24/7/365.
While the Bills have a higher chance of winning the game, betting on the Texans to win is our recommended option due to the 2.2% edge found when comparing our data-driven probabilities to the odds currently available.
Taking advantage of the edges seen on Stats Insider is one of the keys to achieving long-term success as a bettor.
Texans vs Bills: Prediction
Stats Insider's predicted final score for Texans vs Bills at NRG Stadium in Week 12 is the Bills winning 23-19.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Houston vs Buffalo game in Week 12, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.Texans vs Bills: TD Scorer Tips
Who will score the first touchdown in Texans vs Bills? The data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first TD in Texans vs Bills.
Cook has an 11.6% chance of scoring the first TD at NRG Stadium, while the Bills RB has a 51.9% chance of reaching the end zone at any point in the game.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Texans First TD Tips
- Woody Marks: 9.9% probability
- Nico Collins: 8.1% probability
- Dalton Schultz: 3.9% probability
- Jayden Higgins: 3.5% probability
- Nick Chubb: 3.3% probability
Bills First TD Tips
- James Cook: 11.6% probability
- Josh Allen: 10.9% probability
- Khalil Shakir: 5.0% probability
- Dawson Knox: 3.7% probability
- Keon Coleman: 3.4% probability
Anytime Touchdown Scorer Tips
Texans Anytime TD Tips
- Woody Marks: 42.6% probability
- Nico Collins: 36.5% probability
- Dalton Schultz: 19.8% probability
- Jayden Higgins: 17.8% probability
- Nick Chubb: 16.9% probability
Bills Anytime TD Tips
- James Cook: 51.9% probability
- Josh Allen: 49.6% probability
- Khalil Shakir: 27.0% probability
- Dawson Knox: 20.7% probability
- Keon Coleman: 19.4% probability
Texans-Bills Projected Player Stats
Of the starting quarterbacks, the Texans' Davis Mills is projected for 218 passing yards. The Bills' Josh Allen is expected to throw for 231 yards.
Texans Starting QB
- Davis Mills: 218 projected passing yards
Bills Starting QB
- Josh Allen: 231 projected passing yards
Texans Rushing Yards
- Woody Marks: 64 projected yards
- Nick Chubb: 26 projected yards
- Davis Mills: 11 projected yards
Bills Rushing Yards
- James Cook: 81 projected yards
- Josh Allen: 34 projected yards
- Ty Johnson: 16 projected yards
Texans Receiving Yards
- Nico Collins: 75 projected yards
- Dalton Schultz: 42 projected yards
- Jayden Higgins: 34 projected yards
- Xavier Hutchinson: 20 projected yards
- Christian Kirk: 19 projected yards
Bills Receiving Yards
- Khalil Shakir: 49 projected yards
- Joshua Palmer: 35 projected yards
- Gabe Davis: 32 projected yards
- Tyrell Shavers: 30 projected yards
- Dawson Knox: 29 projected yards
Remember, our model updates regularly, so bookmark this article for the latest betting analysis before the Houston vs Buffalo game.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Texans vs Bills: Week 12 Essential Details
The NFL Week 12 match-up between the Texans and Bills at NRG Stadium is scheduled to begin at 12:15pm AEDT on Friday.
- Teams: Houston Texans vs Buffalo Bills
- Date: Friday 21 November 2025
- Time: 12:15pm AEDT
- Venue: NRG Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Houston vs Buffalo predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on NFL
Stats Insider is your go-to source for betting on the NFL in Australia, with the latest NFL betting news, tips for every NFL game, and Super Bowl probabilities for the NFL.
