Texans vs Bills Prediction and Preview - NFL Week 12, 2025

The Houston Texans will sqaure off with the Buffalo Bills in NFL Week 12 action at NRG Stadium on Friday, beginning at 12:15pm AEDT.

This article features Stats Insider's prediction and tips for the Texans vs Bills game, plus the latest betting odds in Australia.

Who Will Win?

Using advanced machine learning and data, Stats Insider has simulated the result of Friday's Houston vs Buffalo NFL game 10,000 times.

Our proven predictive analytics model gives the Bills a 61% chance of beating the Texans at NRG Stadium.

Texans vs Bills: Odds

The current Bet365 betting odds in Australia for Friday's NFL game at NRG Stadium are shown below:

• Head to Head: Texans $2.30, Bills $1.64
• Line: Texans +3 ($1.91), Bills -3 ($1.91)
• Total (Over/Under 44.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Texans at $2.30 and the Bills at $1.64.

The Texans are 3-point underdogs against the Bills, with odds of $1.91 available at Bet365.

For the favourite Bills (-3) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 44.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the Bills (-3) are predicted to cover the line 57% of the time, while the 44.5-point over/under is expected to go over 55% of the time.

Texans vs Bills: Best Bets

• Head to Head: Buffalo at $1.64 with Bet365
• Line: Bills -3 at $1.91 with Bet365
• Total Points: Over 44.5 at $1.91 with Bet365

When you see a 🔥, that means you've found one of our best bets for today across any sport.

These Texans vs Bills betting tips are based on complex simulations and betting experience to bring you the best possible advice 24/7/365.

Texans vs Bills: Prediction

Stats Insider's predicted final score for Texans vs Bills at NRG Stadium in Week 12 is the Bills winning 24-21.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full coverage of the Houston vs Buffalo game in Week 12, including data-driven predictions and live win probabilitiestips.

Remember, our model updates regularly, so bookmark this article for the latest betting predictions before the Houston vs Buffalo game.

As always, see Stats Insider's Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.

Texans vs Bills: Week 12 Essential Details

The NFL Week 12 match-up between the Texans and Bills at NRG Stadium is scheduled to begin at 12:15pm AEDT on Friday.

• Teams: Houston Texans vs Buffalo Bills
• Date: Friday 21 November 2025
• Time: 12:15pm AEDT
• Venue: NRG Stadium

All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.

Conclusion

Our Houston vs Buffalo predictions have been made based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you choose to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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