Texans vs 49ers Prediction and Preview - NFL Week 8, 2025
Last updated: Oct 26, 2025, 4:55PM | Published: Oct 19, 2025, 4:01AM
The Houston Texans will take on the San Francisco 49ers in NFL Week 8 action at NRG Stadium on Monday, commencing at 4:00am AEDT.
This article features Stats Insider's top betting tips for the Texans vs 49ers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Monday's Houston vs San Francisco NFL match-up 10,000 times.
Our proven predictive analytics model gives the Texans a 59% chance of beating the 49ers in Week 8 of the NFL season.
Texans vs 49ers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at NRG Stadium are shown below:
- Head to Head: Texans $1.61, 49ers $2.40
- Line: Texans -3 ($1.91), 49ers +3 ($1.91)
- Total (Over/Under 41 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Texans at $1.61 and the 49ers at $2.40.
The Texans are listed as 3-point favourites against the 49ers, with odds of $1.91 available at Bet365.
For the underdog 49ers (+3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 41 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (+3) are predicted to cover the line 57% of the time, while the 41-point over/under is expected to go over 52% of the time.
Texans vs 49ers: Betting Tips
- Head to Head: San Francisco at $2.40 with Bet365
- Line: 49ers +3 at $1.91 with Bet365
- Total Points: Over 41 at $1.91 with Bet365
When you see a 🔥, that means you've found one of Stats Insider's best tips for today across any sport.
These Texans vs 49ers betting tips are based on complex simulations and wagering expertise to provide you with the best possible advice around the clock.
While the Texans have a higher chance of winning the game, betting on the 49ers to win is our preferred option because of the edge found when comparing our data-driven probabilities to the odds currently on offer.
Taking advantage of the edges published on Stats Insider is pivotal to being a profitable punter in the long run.
Texans vs 49ers: Prediction
Stats Insider's predicted final score for Texans vs 49ers at NRG Stadium in Week 8 is the Texans winning 21-19.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Houston vs San Francisco game in Week 8, including data-driven predictions and live win probabilitiestips.
For in-depth analysis from US experts,, check out Dimers' detailed Texans vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Texans vs 49ers: TD Scorer Tips
Who will score an anytime touchdown in Texans vs 49ers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in Texans vs 49ers.
McCaffrey has a 15.8% chance of scoring the first TD at NRG Stadium, while the 49ers RB has a 58.0% chance of reaching the end zone at any point during the game.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Texans First TD Tips
- Woody Marks: 9.5% probability
- Dalton Schultz: 7.4% probability
- Nick Chubb: 6.6% probability
- Xavier Hutchinson: 5.3% probability
- Jaylin Noel: 5.1% probability
49ers First TD Tips
- Christian McCaffrey: 15.8% probability
- George Kittle: 8.0% probability
- Jauan Jennings: 5.0% probability
- Kendrick Bourne: 3.8% probability
- Brian Robinson: 2.6% probability
Anytime Touchdown Scorer Tips
Texans Anytime TD Tips
- Woody Marks: 36.1% probability
- Dalton Schultz: 29.6% probability
- Nick Chubb: 26.9% probability
- Xavier Hutchinson: 22.1% probability
- Jaylin Noel: 21.5% probability
49ers Anytime TD Tips
- Christian McCaffrey: 58.0% probability
- George Kittle: 35.6% probability
- Jauan Jennings: 23.9% probability
- Kendrick Bourne: 18.9% probability
- Brian Robinson: 13.1% probability
Texans-49ers Projected Player Stats
Of the starting quarterbacks, the Texans' C.J. Stroud is projected for 225 passing yards. The 49ers' Mac Jones is expected to throw for 225 yards.
Texans Starting QB
- C.J. Stroud: 225 projected passing yards
49ers Starting QB
- Mac Jones: 225 projected passing yards
Texans Rushing Yards
- Woody Marks: 41 projected yards
- Nick Chubb: 37 projected yards
- C.J. Stroud: 17 projected yards
49ers Rushing Yards
- Christian McCaffrey: 72 projected yards
- Brian Robinson: 18 projected yards
- Mac Jones: 10 projected yards
Texans Receiving Yards
- Dalton Schultz: 52 projected yards
- Jaylin Noel: 42 projected yards
- Jayden Higgins: 38 projected yards
- Xavier Hutchinson: 33 projected yards
- Woody Marks: 22 projected yards
49ers Receiving Yards
- George Kittle: 53 projected yards
- Jauan Jennings: 46 projected yards
- Christian McCaffrey: 46 projected yards
- Kendrick Bourne: 40 projected yards
- Demarcus Robinson: 19 projected yards
Our model updates frequently, so refresh this article for the latest betting predictions before the Houston vs San Francisco game.
As always, see Stats Insider's Best Bets for betting tips for every NFL game, as well as predictions for a wide range of other sports.
Texans vs 49ers: Week 8 Essential Details
The NFL Week 8 match-up between the Texans and 49ers at NRG Stadium is scheduled to start at 4:00am AEDT on Monday.
- Teams: Houston Texans vs San Francisco 49ers
- Date: Monday 27 October 2025
- Time: 4:00am AEDT
- Venue: NRG Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Houston vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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