Steelers vs Bills Prediction and Preview - NFL Week 13, 2025
Last updated: Nov 23, 2025, 9:21AM | Published: Nov 23, 2025, 7:44AM
The Pittsburgh Steelers will sqaure off with the Buffalo Bills in NFL Week 13 action at Acrisure Stadium on Monday, December 1, starting at 8:25am AEDT.
This article features Stats Insider's prediction and tips for the Steelers vs Bills game, plus the latest betting odds in Australia.
Who Will Win?
Based on trusted machine learning and data, Stats Insider has simulated the result of Bills vs Steelers 10,000 times.
Our proven predictive analytics model gives the Bills a 64% chance of beating the Steelers in Week 13 of the NFL season.
Steelers vs Bills: Odds
The latest Bet365 betting odds in Australia for this NFL game at Acrisure Stadium are shown below:
- Head to Head: Steelers $2.55, Bills $1.54
- Line: Steelers +3.5 ($1.91), Bills -3.5 ($1.91)
- Total (Over/Under 47 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Steelers at $2.55 and the Bills at $1.54.
The Steelers are 3.5-point underdogs against the Bills, with odds of $1.91 available at Bet365.
For the favourite Bills (-3.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Bills (-3.5) are predicted to cover the line 52% of the time, while the 47-point over/under is expected to stay under 52% of the time.
Steelers vs Bills: Betting Tips
- Head to Head: Buffalo at $1.54 with Bet365
- Line: Bills -3.5 at $1.91 with Bet365
- Total Points: Under 47 at $1.91 with Bet365
Our Steelers vs Bills predictions are based on market-leading modelling and betting experience to provide you with the best possible advice 24/7.
Steelers vs Bills: Prediction
Stats Insider's predicted final score for Steelers vs Bills at Acrisure Stadium in Week 13 is the Bills winning 25-21.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Pittsburgh vs Buffalo game in Week 13, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so bookmark this article for the latest betting analysis before the Pittsburgh vs Buffalo match-up.
As always, see our Best Bets to get betting tips on every NFL game, plus predictions for a wide range of other sports.
Steelers vs Bills: Week 13 Essential Details
The NFL Week 13 match-up between the Steelers and Bills at Acrisure Stadium is scheduled to start at 8:25am AEDT on Monday, December 1.
- Teams: Pittsburgh Steelers vs Buffalo Bills
- Date: Monday 1 December 2025
- Time: 8:25am AEDT
- Venue: Acrisure Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Pittsburgh vs Buffalo predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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