Seahawks vs Colts Prediction and Preview - NFL Week 15, 2025
Last updated: Dec 8, 2025, 5:15AM | Published: Dec 7, 2025, 5:00AM
The Seattle Seahawks will face the Indianapolis Colts in NFL Week 15 action at Lumen Field on Monday, commencing at 8:25am AEDT.
This article features Stats Insider's prediction and tips for the Seahawks vs Colts game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Seattle vs Indianapolis NFL game 10,000 times.
Our independent predictive analytics model currently gives the Seahawks a 61% chance of winning against the Colts at Lumen Field.
Seahawks vs Colts: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Lumen Field are listed here:
- Head to Head: Seahawks $1.17, Colts $5.50
- Line: Seahawks -10.5 ($1.91), Colts +10.5 ($1.91)
- Total (Over/Under 43.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Seahawks at $1.17 and the Colts at $5.50.
The Seahawks are 10.5-point favourites against the Colts, with odds of $1.91 available at Bet365.
For the underdog Colts (+10.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Colts (+10.5) are predicted to cover the line 85% of the time, while the 43.5-point over/under is expected to go over 59% of the time.
Seahawks vs Colts: Best Bets
- Head to Head: Indianapolis at $5.50 with Bet365
- Line: Colts +10.5 at $1.91 with Bet365
- Total Points: Over 43.5 at $1.91 with Bet365
If you see a 🔥, you know you've found one of our best tips of the day across all sports.
Stats Insider's Seahawks vs Colts best bets are based on market-leading modelling and wagering intelligence to help you place more informed bets with your chosen online bookie.
While the Seahawks have a higher chance of winning the game, betting on the Colts to win is our recommended option due to the 20.6% edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published here at Stats Insider is one of the keys to being a profitable sports bettor in the long run.
Seahawks vs Colts: Prediction
Stats Insider's predicted final score for Seahawks vs Colts at Lumen Field in Week 15 is the Seahawks winning 25-21.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Seattle vs Indianapolis game in Week 15, including data-driven predictions and computer tips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates frequently, so refresh this page for the latest betting predictions before the Seattle vs Indianapolis game.
As always, see Stats Insider's Best Bets to get the best tips for every NFL game, as well as predictions for a wide range of other sports.
Seahawks vs Colts: Week 15 Essential Details
The NFL Week 15 game between the Seahawks and Colts at Lumen Field is scheduled to commence at 8:25am AEDT on Monday.
- Teams: Seattle Seahawks vs Indianapolis Colts
- Date: Monday 15 December 2025
- Time: 8:25am AEDT
- Venue: Lumen Field
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Seattle vs Indianapolis predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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