Seahawks vs Cardinals Prediction and Preview - NFL Week 10, 2025
Last updated: Nov 9, 2025, 9:05PM | Published: Nov 2, 2025, 4:05AM
The Seattle Seahawks will take on the Arizona Cardinals in NFL Week 10 action at Lumen Field on Monday, commencing at 8:05am AEDT.
This article features Stats Insider's prediction and tips for the Seahawks vs Cardinals game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the result of Monday's Seattle vs Arizona NFL match-up 10,000 times.
Our independent predictive analytics model gives the Seahawks a 74% chance of beating the Cardinals in Week 10 of the NFL season.
Seahawks vs Cardinals: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Lumen Field are listed below:
- Head to Head: Seahawks $1.27, Cardinals $3.90
- Line: Seahawks -7 ($1.91), Cardinals +7 ($1.91)
- Total (Over/Under 44.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Seahawks at $1.27 and the Cardinals at $3.90.
The Seahawks are 7-point favourites against the Cardinals, with odds of $1.91 available at Bet365.
For the underdog Cardinals (+7) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 44.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Seahawks and the Cardinals have a 50% chance of covering the line.
The 44.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Seahawks vs Cardinals: Best Bets
- Head to Head: Arizona at $3.90 with Bet365
- Line: Cardinals +7 at $1.91 with Bet365
- Total Points: Under 44.5 at $1.91 with Bet365
Stats Insider's Seahawks vs Cardinals best bets are based on complex modelling and wagering expertise to give you the best possible advice around the clock.
While the Seahawks have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is pivotal to being a profitable bettor in the long run.
Seahawks vs Cardinals: Prediction
Stats Insider's predicted final score for Seahawks vs Cardinals at Lumen Field in Week 10 is the Seahawks winning 25-18.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Seattle vs Arizona game in Week 10, including data-driven predictions and live win probabilitiestips.
For in-depth analysis from US experts,, check out Dimers' detailed Seahawks vs Cardinals prediction.
18+. Odds correct at time of publishing and subject to change.Seahawks vs Cardinals: TD Scorer Tips
Who will score the first touchdown in Seahawks vs Cardinals? The data is in.
According to Stats Insider, Seattle's Jaxon Smith-Njigba is the most likely player to score the first TD in Seahawks vs Cardinals.
Smith-Njigba has a 10.9% chance of getting in for six first at Lumen Field, while the Seahawks WR has a 45.8% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Seahawks First TD Tips
- Jaxon Smith-Njigba: 10.9% probability
- Zach Charbonnet: 9.2% probability
- Kenneth Walker: 7.8% probability
- Rashid Shaheed: 5.9% probability
- AJ Barner: 5.5% probability
Cardinals First TD Tips
- Trey McBride: 7.8% probability
- Marvin Harrison: 7.2% probability
- Bam Knight: 6.1% probability
- Emari Demercado: 6.0% probability
- Michael Wilson: 4.1% probability
Anytime Touchdown Scorer Tips
Seahawks Anytime TD Tips
- Jaxon Smith-Njigba: 45.8% probability
- Zach Charbonnet: 40.5% probability
- Kenneth Walker: 35.6% probability
- Rashid Shaheed: 28.2% probability
- AJ Barner: 26.6% probability
Cardinals Anytime TD Tips
- Trey McBride: 33.5% probability
- Marvin Harrison: 31.3% probability
- Bam Knight: 27.5% probability
- Emari Demercado: 27.0% probability
- Michael Wilson: 19.3% probability
Seahawks-Cardinals Projected Player Stats
Of the starting quarterbacks, the Seahawks' Sam Darnold is projected for 252 passing yards, while the Cardinals' Jacoby Brissett is expected to throw for 235 yards.
Seahawks Starting QB
- Sam Darnold: 252 projected passing yards
Cardinals Starting QB
- Jacoby Brissett: 235 projected passing yards
Seahawks Rushing Yards
- Kenneth Walker: 58 projected yards
- Zach Charbonnet: 42 projected yards
- Sam Darnold: 8 projected yards
Cardinals Rushing Yards
- Emari Demercado: 42 projected yards
- Bam Knight: 32 projected yards
- Jacoby Brissett: 16 projected yards
Seahawks Receiving Yards
- Jaxon Smith-Njigba: 101 projected yards
- Rashid Shaheed: 39 projected yards
- Cooper Kupp: 33 projected yards
- AJ Barner: 30 projected yards
- Elijah Arroyo: 23 projected yards
Cardinals Receiving Yards
- Trey McBride: 64 projected yards
- Marvin Harrison: 59 projected yards
- Michael Wilson: 34 projected yards
- Zay Jones: 20 projected yards
- Bam Knight: 15 projected yards
Our model updates regularly, so bookmark this article for the latest betting tips before the Seattle vs Arizona match-up.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, as well as predictions for a wide range of other sports.
Seahawks vs Cardinals: Week 10 Essential Details
The NFL Week 10 game between the Seahawks and Cardinals at Lumen Field is scheduled to begin at 8:05am AEDT on Monday.
- Teams: Seattle Seahawks vs Arizona Cardinals
- Date: Monday 10 November 2025
- Time: 8:05am AEDT
- Venue: Lumen Field
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Seattle vs Arizona predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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