Seahawks vs 49ers Prediction and Preview - NFL Week 1, 2025
Last updated: Sep 7, 2025, 8:05PM | Published: Aug 19, 2025, 6:04PM
The Seattle Seahawks will face the San Francisco 49ers in NFL Week 1 action at Lumen Field on Monday, beginning at 6:05am AEST.
This article features Stats Insider's prediction and tips for the Seahawks vs 49ers game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the outcome of Monday's Seattle vs San Francisco NFL match-up 10,000 times.
Our leading predictive analytics model gives the 49ers a 59% chance of winning against the Seahawks in Week 1 of the NFL season.
Seahawks vs 49ers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Lumen Field are listed below:
- Head to Head: Seahawks $2.15, 49ers $1.74
- Line: Seahawks +1.5 ($1.91), 49ers -1.5 ($1.91)
- Total (Over/Under 43.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Seahawks at $2.15 and the 49ers at $1.74.
The Seahawks are 1.5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-1.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the 49ers (-1.5) are predicted to cover the line 53% of the time, while the 43.5-point over/under is expected to stay under 56% of the time.
Seahawks vs 49ers: Betting Tips
- Head to Head: San Francisco at $1.74 with Bet365
- Line: 49ers -1.5 at $1.91 with Bet365
- Total Points: Under 43.5 at $1.91 with Bet365
If you see a 🔥, that means you've found one of our best bets for today across all sports.
These Seahawks vs 49ers best bets are based on market-leading simulations and gambling experience to provide you with the best possible advice 24/7.
Seahawks vs 49ers: Prediction
Stats Insider's predicted final score for Seahawks vs 49ers at Lumen Field in Week 1 is the 49ers winning 22-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full betting coverage of the Seattle vs San Francisco game in Week 1, including data-driven predictions and live win probabilitiestips.
For in-depth analysis from US experts,, check out Dimers' detailed Seahawks vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Seahawks vs 49ers: TD Scorer Tips
Who will score the first touchdown in Seahawks vs 49ers? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in Seahawks vs 49ers.
McCaffrey has a 13.8% chance of scoring the first TD at Lumen Field, while the 49ers RB has a 49.0% chance of reaching the end zone at any point in the game.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Seahawks First TD Tips
- Kenneth Walker: 10.4% probability
- Jaxon Smith-Njigba: 7.8% probability
- Zach Charbonnet: 6.7% probability
- Cooper Kupp: 6.5% probability
- AJ Barner: 3.3% probability
49ers First TD Tips
- Christian McCaffrey: 13.8% probability
- George Kittle: 8.3% probability
- Ricky Pearsall: 6.4% probability
- Jauan Jennings: 6.3% probability
- Brian Robinson: 4.3% probability
Anytime Touchdown Scorer Tips
Seahawks Anytime TD Tips
- Kenneth Walker: 42.5% probability
- Jaxon Smith-Njigba: 33.8% probability
- Zach Charbonnet: 29.9% probability
- Cooper Kupp: 29.0% probability
- AJ Barner: 16.0% probability
49ers Anytime TD Tips
- Christian McCaffrey: 49.0% probability
- George Kittle: 33.3% probability
- Ricky Pearsall: 26.8% probability
- Jauan Jennings: 26.3% probability
- Brian Robinson: 19.0% probability
Seahawks-49ers Projected Player Stats
Of the starting quarterbacks, the Seahawks' Sam Darnold is projected for 218 passing yards, while the 49ers' Brock Purdy is expected to throw for 245 yards.
Seahawks Starting QB
- Sam Darnold: 218 projected passing yards
49ers Starting QB
- Brock Purdy: 245 projected passing yards
Seahawks Rushing Yards
- Kenneth Walker: 59 projected yards
- Zach Charbonnet: 33 projected yards
- Sam Darnold: 11 projected yards
49ers Rushing Yards
- Christian McCaffrey: 72 projected yards
- Brian Robinson: 19 projected yards
- Brock Purdy: 17 projected yards
Seahawks Receiving Yards
- Jaxon Smith-Njigba: 65 projected yards
- Cooper Kupp: 46 projected yards
- Tory Horton: 30 projected yards
- AJ Barner: 24 projected yards
- Kenneth Walker: 18 projected yards
49ers Receiving Yards
- George Kittle: 62 projected yards
- Jauan Jennings: 53 projected yards
- Ricky Pearsall: 52 projected yards
- Christian McCaffrey: 32 projected yards
- Russell Gage: 11 projected yards
Remember, our model updates frequently, so refresh this article for the latest betting analysis before the Seattle vs San Francisco game.
As always, see our Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Seahawks vs 49ers: Week 1 Essential Details
The NFL Week 1 game between the Seahawks and 49ers at Lumen Field is scheduled to begin at 6:05am AEST on Monday.
- Teams: Seattle Seahawks vs San Francisco 49ers
- Date: Monday 8 September 2025
- Time: 6:05am AEST
- Venue: Lumen Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Seattle vs San Francisco predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's vital to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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