Seahawks vs 49ers Prediction and Preview - NFL Week 1, 2025

The Seattle Seahawks will face the San Francisco 49ers in NFL Week 1 action at Lumen Field on Monday, September 8, starting at 6:05am AEST.

This article features Stats Insider's best betting tips for the Seahawks vs 49ers game, as well as the latest betting odds in Australia.

Who Will Win?

Utilising trusted machine learning and data, Stats Insider has simulated the result of 49ers vs Seahawks 10,000 times.

Our proven predictive analytics model currently gives the 49ers a 58% chance of winning against the Seahawks at Lumen Field.

Seahawks vs 49ers: Odds

The latest Bet365 betting odds in Australia for this NFL game at Lumen Field are shown below:

• Head to Head: Seahawks $2.20, 49ers $1.71
• Line: Seahawks +2.5 ($1.91), 49ers -2.5 ($1.91)
• Total (Over/Under 45 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Seahawks at $2.20 and the 49ers at $1.71.

The Seahawks are 2.5-point underdogs against the 49ers, with odds of $1.91 available at Bet365.

For the favourite 49ers (-2.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 45 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the bookmakers have got it right and both the Seahawks and the 49ers have a 50% chance of covering the line.

The 45-point over/under is expected to stay under 51% of the time.

Seahawks vs 49ers: Best Bets

• Head to Head: San Francisco at $1.71 with Bet365
• Line: 49ers -2.5 at $1.91 with Bet365
• Total Points: Under 45 at $1.91 with Bet365

These Seahawks vs 49ers best bets are based on complex modelling and wagering intelligence to provide you with the best possible advice 24/7.

Seahawks vs 49ers: Prediction

Stats Insider's predicted final score for Seahawks vs 49ers at Lumen Field in Week 1 is the 49ers winning 23-21.

This prediction is based on each team's average score following 10,000 game simulations.

Stats Insider provides full betting coverage of the Seattle vs San Francisco game in Week 1, including data-driven predictions and computer tips.

Remember, our model updates regularly, so bookmark this page for the latest betting predictions before the Seattle vs San Francisco game.

As always, see our Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.

Seahawks vs 49ers: Week 1 Essential Details

The NFL Week 1 match-up between the Seahawks and 49ers at Lumen Field is scheduled to begin at 6:05am AEST on Monday, September 8.

• Teams: Seattle Seahawks vs San Francisco 49ers
• Date: Monday 8 September 2025
• Time: 6:05am AEST
• Venue: Lumen Field

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our Seattle vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you decide to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on NFL

Stats Insider is your home for betting on the NFL in Australia, with the latest NFL betting news, tips for every NFL game, and Super Bowl probabilities for the NFL.