Saints vs Cardinals Prediction and Preview - NFL Week 1, 2025
Last updated: Sep 7, 2025, 5:02PM | Published: Aug 19, 2025, 6:05PM
The New Orleans Saints will take on the favoured Arizona Cardinals in NFL Week 1 action at Caesars Superdome on Monday, beginning at 3:00am AEST.
This article features Stats Insider's prediction and tips for the Saints vs Cardinals game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the outcome of Monday's New Orleans vs Arizona NFL match-up 10,000 times.
Our proven predictive analytics model currently gives the Cardinals a 72% chance of winning against the Saints at Caesars Superdome.
Saints vs Cardinals: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Caesars Superdome are listed here:
- Head to Head: Saints $3.00, Cardinals $1.41
- Line: Saints +5.5 ($1.91), Cardinals -5.5 ($1.91)
- Total (Over/Under 44.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Saints at $3.00 and the Cardinals at $1.41.
The Saints are 5.5-point underdogs against the Cardinals, with odds of $1.91 available at Bet365.
For the favourite Cardinals (-5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 44.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Saints (+5.5) are predicted to cover the line 51% of the time, while the 44.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Saints vs Cardinals: Best Bets
- Head to Head: Arizona at $1.41 with Bet365
- Line: Saints +5.5 at $1.91 with Bet365
- Total Points: Under 44.5 at $1.91 with Bet365
Our Saints vs Cardinals best bets are based on world-class modelling and wagering intelligence to bring you the best possible advice every day of the year.
Saints vs Cardinals: Prediction
Stats Insider's predicted final score for Saints vs Cardinals at Caesars Superdome in Week 1 is the Cardinals winning 25-19.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the New Orleans vs Arizona game in Week 1, including data-driven predictions and live updatestips.
Get expert analysis from the US with Dimers' in-depth Saints vs Cardinals prediction.
18+. Odds correct at time of publishing and subject to change.Saints vs Cardinals: TD Scorer Tips
Who will score the first touchdown in Saints vs Cardinals? The data is in.
According to Stats Insider, Arizona's James Conner is the most likely player to score the first TD in Saints vs Cardinals.
Conner has a 16.7% chance of scoring the first TD at Caesars Superdome, while the Cardinals RB has a 52.3% chance of scoring an anytime touchdown.
Scroll down for the full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Saints First TD Tips
- Alvin Kamara: 13.5% probability
- Chris Olave: 6.6% probability
- Rashid Shaheed: 5.7% probability
- Juwan Johnson: 3.9% probability
- Brandin Cooks: 2.8% probability
Cardinals First TD Tips
- James Conner: 16.7% probability
- Marvin Harrison: 9.0% probability
- Trey McBride: 7.3% probability
- Kyler Murray: 6.3% probability
- Michael Wilson: 4.2% probability
Anytime Touchdown Scorer Tips
Saints Anytime TD Tips
- Alvin Kamara: 45.8% probability
- Chris Olave: 25.8% probability
- Rashid Shaheed: 22.9% probability
- Juwan Johnson: 16.2% probability
- Brandin Cooks: 11.8% probability
Cardinals Anytime TD Tips
- James Conner: 52.3% probability
- Marvin Harrison: 33.0% probability
- Trey McBride: 27.7% probability
- Kyler Murray: 24.2% probability
- Michael Wilson: 16.9% probability
Saints-Cardinals Projected Player Stats
Of the starting quarterbacks, the Saints' Spencer Rattler is projected for 209 passing yards, while the Cardinals' Kyler Murray is expected to throw for 227 yards.
Saints Starting QB
- Spencer Rattler: 209 projected passing yards
Cardinals Starting QB
- Kyler Murray: 227 projected passing yards
Saints Rushing Yards
- Alvin Kamara: 65 projected yards
- Spencer Rattler: 23 projected yards
- Kendre Miller: 23 projected yards
Cardinals Rushing Yards
- James Conner: 76 projected yards
- Kyler Murray: 30 projected yards
- Trey Benson: 29 projected yards
Saints Receiving Yards
- Chris Olave: 57 projected yards
- Rashid Shaheed: 46 projected yards
- Alvin Kamara: 32 projected yards
- Juwan Johnson: 30 projected yards
- Brandin Cooks: 23 projected yards
Cardinals Receiving Yards
- Trey McBride: 65 projected yards
- Marvin Harrison: 63 projected yards
- Michael Wilson: 31 projected yards
- Zay Jones: 19 projected yards
- James Conner: 19 projected yards
Remember, our model updates frequently, so bookmark this page for the latest betting tips before the New Orleans vs Arizona game.
As always, see our Best Bets for betting tips for every NFL game, plus predictions for a wide range of other sports.
Saints vs Cardinals: Week 1 Essential Details
The NFL Week 1 game between the Saints and Cardinals at Caesars Superdome is scheduled to commence at 3:00am AEST on Monday.
- Teams: New Orleans Saints vs Arizona Cardinals
- Date: Monday 8 September 2025
- Time: 3:00am AEST
- Venue: Caesars Superdome
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our New Orleans vs Arizona predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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