Saints vs Cardinals Prediction and Preview - NFL Week 1, 2025

The New Orleans Saints will sqaure off with the favoured Arizona Cardinals in NFL Week 1 action at Caesars Superdome on Monday, September 8, beginning at 3:00am AEST.

This article features Stats Insider's prediction and tips for the Saints vs Cardinals game, as well as the latest betting odds in Australia.

Who Will Win?

Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Cardinals vs Saints 10,000 times.

Our leading predictive analytics model gives the Cardinals a 72% chance of winning against the Saints in Week 1 of the NFL season.

Saints vs Cardinals: Odds

The latest Bet365 betting odds in Australia for this NFL game at Caesars Superdome are listed here:

• Head to Head: Saints $3.10, Cardinals $1.37
• Line: Saints +6 ($1.91), Cardinals -6 ($1.91)
• Total (Over/Under 42.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Saints at $3.10 and the Cardinals at $1.37.

The Saints are 6-point underdogs against the Cardinals, with odds of $1.91 available at Bet365.

For the favourite Cardinals (-6) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the bookmakers have got it right and both the Saints and the Cardinals have a 50% chance of covering the line.

The 42.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.

Saints vs Cardinals: Best Bets

• Head to Head: Arizona at $1.37 with Bet365
• Line: Cardinals -6 at $1.91 with Bet365
• Total Points: Under 42.5 at $1.91 with Bet365

Our Saints vs Cardinals best bets are based on market-leading modelling and betting expertise to help you place better bets with your chosen online bookie.

Saints vs Cardinals: Prediction

Stats Insider's predicted final score for Saints vs Cardinals at Caesars Superdome in Week 1 is the Cardinals winning 23-18.

This prediction is based on each team's average score following 10,000 game simulations.

Stats Insider provides full coverage of the New Orleans vs Arizona game in Week 1, including data-driven predictions and the best betting tips.

Our model updates frequently, so bookmark this page for the latest betting tips before the New Orleans vs Arizona match-up.

As always, see Stats Insider's Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.

Saints vs Cardinals: Week 1 Essential Details

The NFL Week 1 match-up between the Saints and Cardinals at Caesars Superdome is scheduled to begin at 3:00am AEST on Monday, September 8.

• Teams: New Orleans Saints vs Arizona Cardinals
• Date: Monday 8 September 2025
• Time: 3:00am AEST
• Venue: Caesars Superdome

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our New Orleans vs Arizona predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you decide to use our NFL predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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