Saints vs Cardinals Prediction and Preview - NFL Week 1, 2025
Last updated: Aug 19, 2025, 6:00PM | Published: Aug 19, 2025, 4:30PM
The New Orleans Saints will sqaure off with the favoured Arizona Cardinals in NFL Week 1 action at Caesars Superdome on Monday, September 8, starting at 3:00am AEST.
This article features Stats Insider's top betting tips for the Saints vs Cardinals game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the result of Cardinals vs Saints 10,000 times.
Our proven predictive analytics model gives the Cardinals a 70% chance of defeating the Saints in Week 1 of the NFL season.
Saints vs Cardinals: Odds
The current Bet365 betting odds in Australia for this NFL game at Caesars Superdome are listed below:
- Head to Head: Saints $3.10, Cardinals $1.38
- Line: Saints +6 ($1.91), Cardinals -6 ($1.91)
- Total (Over/Under 42.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Saints at $3.10 and the Cardinals at $1.38.
The Saints are listed as 6-point underdogs against the Cardinals, with odds of $1.91 available at Bet365.
For the favourite Cardinals (-6) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Saints (+6) are predicted to cover the line 53% of the time, while the 42.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Saints vs Cardinals: Best Bets
- Head to Head: New Orleans at $3.10 with Bet365
- Line: Saints +6 at $1.91 with Bet365
- Total Points: Under 42.5 at $1.91 with Bet365
These Saints vs Cardinals betting tips are based on market-leading modelling and gambling expertise to help you place more informed bets with your chosen online bookie.
While the Cardinals have a higher chance of winning the game, betting on the Saints to win is our preferred option because of the edge identified when comparing our data-led probabilities to the odds currently on offer.
Taking advantage of the edges published on Stats Insider is one of the keys to being a profitable sports bettor in the long run.
Saints vs Cardinals: Prediction
Stats Insider's predicted final score for Saints vs Cardinals at Caesars Superdome in Week 1 is the Cardinals winning 23-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the New Orleans vs Arizona game in Week 1, including data-driven predictions and top betting tips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so refresh this article for the latest betting analysis before the New Orleans vs Arizona match-up.
As always, see our Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Saints vs Cardinals: Week 1 Essential Details
The NFL Week 1 match-up between the Saints and Cardinals at Caesars Superdome is scheduled to start at 3:00am AEST on Monday, September 8.
- Teams: New Orleans Saints vs Arizona Cardinals
- Date: Monday 8 September 2025
- Time: 3:00am AEST
- Venue: Caesars Superdome
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our New Orleans vs Arizona predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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