Saints vs 49ers Prediction and Preview - NFL Week 2, 2025
Last updated: Sep 14, 2025, 5:01PM | Published: Sep 7, 2025, 4:02AM
The New Orleans Saints will take on the San Francisco 49ers in NFL Week 2 action at Caesars Superdome on Monday, commencing at 3:00am AEST.
This article features Stats Insider's prediction and tips for the Saints vs 49ers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the result of Monday's New Orleans vs San Francisco NFL game 10,000 times.
Our independent predictive analytics model currently gives the 49ers a 64% chance of defeating the Saints in Week 2 of the NFL season.
Saints vs 49ers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Caesars Superdome are listed here:
- Head to Head: Saints $2.35, 49ers $1.62
- Line: Saints +3 ($1.91), 49ers -3 ($1.91)
- Total (Over/Under 40.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Saints at $2.35 and the 49ers at $1.62.
The Saints are 3-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 40.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookies have got it right and both the Saints and the 49ers have a 50% chance of covering the line.
The 40.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Saints vs 49ers: Betting Tips
- Head to Head: San Francisco at $1.62 with Bet365
- Line: 49ers -3 at $1.91 with Bet365
- Total Points: Under 40.5 at $1.91 with Bet365
These Saints vs 49ers betting tips are based on world-class simulations and betting expertise to give you the best possible advice 24/7/365.
Saints vs 49ers: Prediction
Stats Insider's predicted final score for Saints vs 49ers at Caesars Superdome in Week 2 is the 49ers winning 21-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the New Orleans vs San Francisco game in Week 2, including data-driven predictions and top betting tips.
For in-depth analysis from US experts,, check out Dimers' detailed Saints vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Saints vs 49ers: TD Scorer Tips
Who will score the first touchdown in Saints vs 49ers? The data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in Saints vs 49ers.
McCaffrey has a 16.7% chance of scoring the first TD at Caesars Superdome, while the 49ers RB has a 52.9% chance of registering an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Saints First TD Tips
- Alvin Kamara: 14.0% probability
- Chris Olave: 6.8% probability
- Rashid Shaheed: 6.2% probability
- Juwan Johnson: 5.6% probability
- Kendre Miller: 3.0% probability
49ers First TD Tips
- Christian McCaffrey: 16.7% probability
- Ricky Pearsall: 6.9% probability
- Jauan Jennings: 6.0% probability
- Brian Robinson: 5.5% probability
- Kyle Juszczyk: 2.8% probability
Anytime Touchdown Scorer Tips
Saints Anytime TD Tips
- Alvin Kamara: 44.5% probability
- Chris Olave: 24.9% probability
- Rashid Shaheed: 23.1% probability
- Juwan Johnson: 21.0% probability
- Kendre Miller: 12.0% probability
49ers Anytime TD Tips
- Christian McCaffrey: 52.9% probability
- Ricky Pearsall: 26.6% probability
- Jauan Jennings: 23.7% probability
- Brian Robinson: 22.0% probability
- Kyle Juszczyk: 11.9% probability
Saints-49ers Projected Player Stats
Of the starting quarterbacks, the Saints' Spencer Rattler is projected for 210 passing yards. The 49ers' Mac Jones is expected to throw for 206 yards.
Saints Starting QB
- Spencer Rattler: 210 projected passing yards
49ers Starting QB
- Mac Jones: 206 projected passing yards
Saints Rushing Yards
- Alvin Kamara: 53 projected yards
- Spencer Rattler: 22 projected yards
- Kendre Miller: 19 projected yards
49ers Rushing Yards
- Christian McCaffrey: 87 projected yards
- Brian Robinson: 31 projected yards
- Mac Jones: 8 projected yards
Saints Receiving Yards
- Chris Olave: 60 projected yards
- Rashid Shaheed: 47 projected yards
- Juwan Johnson: 40 projected yards
- Alvin Kamara: 26 projected yards
- Brandin Cooks: 21 projected yards
49ers Receiving Yards
- Ricky Pearsall: 61 projected yards
- Jauan Jennings: 45 projected yards
- Christian McCaffrey: 36 projected yards
- Jake Tonges: 19 projected yards
- Luke Farrell: 12 projected yards
Our model updates regularly, so keep checking this page for the latest betting tips before the New Orleans vs San Francisco game.
As always, see our Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.
Saints vs 49ers: Week 2 Essential Details
The NFL Week 2 game between the Saints and 49ers at Caesars Superdome is scheduled to begin at 3:00am AEST on Monday.
- Teams: New Orleans Saints vs San Francisco 49ers
- Date: Monday 15 September 2025
- Time: 3:00am AEST
- Venue: Caesars Superdome
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our New Orleans vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's important that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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