Saints vs 49ers Prediction and Preview - NFL Week 2, 2025
Last updated: Sep 14, 2025, 8:31AM | Published: Sep 7, 2025, 4:02AM
The New Orleans Saints will sqaure off with the San Francisco 49ers in NFL Week 2 action at Caesars Superdome on Monday, starting at 3:00am AEST.
This article features Stats Insider's best betting tips for the Saints vs 49ers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the result of Monday's New Orleans vs San Francisco NFL game 10,000 times.
Our independent predictive analytics model gives the 49ers a 64% chance of defeating the Saints in Week 2 of the NFL season.
Saints vs 49ers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Caesars Superdome are shown below:
- Head to Head: Saints $2.35, 49ers $1.62
- Line: Saints +3 ($1.91), 49ers -3 ($1.91)
- Total (Over/Under 40.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Saints at $2.35 and the 49ers at $1.62.
The Saints are 3-point underdogs against the 49ers, with odds of $1.91 available at Bet365.
For the favourite 49ers (-3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 40.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Saints and the 49ers have a 50% chance of covering the line.
The 40.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.
Saints vs 49ers: Betting Tips
- Head to Head: San Francisco at $1.62 with Bet365
- Line: 49ers -3 at $1.91 with Bet365
- Total Points: Under 40.5 at $1.91 with Bet365
Stats Insider's Saints vs 49ers betting tips are based on complex modelling and gambling intelligence to help you place better bets with your chosen online bookie.
Saints vs 49ers: Prediction
Stats Insider's predicted final score for Saints vs 49ers at Caesars Superdome in Week 2 is the 49ers winning 21-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the New Orleans vs San Francisco game in Week 2, including data-driven predictions and free tips.
For in-depth analysis from US experts,, check out Dimers' detailed Saints vs 49ers prediction.
18+. Odds correct at time of publishing and subject to change.Saints vs 49ers: TD Scorer Tips
Who will score the first touchdown in Saints vs 49ers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first TD in Saints vs 49ers.
McCaffrey has a 16.3% chance of scoring the first TD at Caesars Superdome, while the 49ers RB has a 53.1% chance of registering an anytime touchdown.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Saints First TD Tips
- Alvin Kamara: 14.2% probability
- Chris Olave: 6.7% probability
- Rashid Shaheed: 6.1% probability
- Juwan Johnson: 5.5% probability
- Kendre Miller: 3.0% probability
49ers First TD Tips
- Christian McCaffrey: 16.3% probability
- Ricky Pearsall: 6.7% probability
- Jauan Jennings: 6.0% probability
- Brian Robinson: 5.3% probability
- Kyle Juszczyk: 2.4% probability
Anytime Touchdown Scorer Tips
Saints Anytime TD Tips
- Alvin Kamara: 45.5% probability
- Chris Olave: 25.1% probability
- Rashid Shaheed: 23.1% probability
- Juwan Johnson: 21.1% probability
- Kendre Miller: 12.1% probability
49ers Anytime TD Tips
- Christian McCaffrey: 53.1% probability
- Ricky Pearsall: 26.8% probability
- Jauan Jennings: 24.3% probability
- Brian Robinson: 21.8% probability
- Kyle Juszczyk: 10.5% probability
Saints-49ers Projected Player Stats
Of the starting quarterbacks, the Saints' Spencer Rattler is projected for 210 passing yards. The 49ers' Mac Jones is expected to throw for 206 yards.
Saints Starting QB
- Spencer Rattler: 210 projected passing yards
49ers Starting QB
- Mac Jones: 206 projected passing yards
Saints Rushing Yards
- Alvin Kamara: 54 projected yards
- Spencer Rattler: 22 projected yards
- Kendre Miller: 19 projected yards
49ers Rushing Yards
- Christian McCaffrey: 86 projected yards
- Brian Robinson: 31 projected yards
- Mac Jones: 8 projected yards
Saints Receiving Yards
- Chris Olave: 60 projected yards
- Rashid Shaheed: 46 projected yards
- Juwan Johnson: 40 projected yards
- Alvin Kamara: 26 projected yards
- Brandin Cooks: 24 projected yards
49ers Receiving Yards
- Ricky Pearsall: 61 projected yards
- Jauan Jennings: 45 projected yards
- Christian McCaffrey: 36 projected yards
- Jake Tonges: 18 projected yards
- Kyle Juszczyk: 11 projected yards
Remember, our model updates regularly, so refresh this page for the latest betting predictions before the New Orleans vs San Francisco game.
As always, see our Best Bets for betting tips for every NFL game, as well as predictions for a wide range of other sports.
Saints vs 49ers: Week 2 Essential Details
The NFL Week 2 game between the Saints and 49ers at Caesars Superdome is scheduled to start at 3:00am AEST on Monday.
- Teams: New Orleans Saints vs San Francisco 49ers
- Date: Monday 15 September 2025
- Time: 3:00am AEST
- Venue: Caesars Superdome
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our New Orleans vs San Francisco predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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