Reds vs Pirates Prediction and MLB Tips - 26 September 2025
Last updated: Sep 25, 2025, 6:01PM | Published: Sep 24, 2025, 6:29PM
The Cincinnati Reds will face the Pittsburgh Pirates in Game of the League Series at Great American Ball Park on Friday, starting at 2:40am AEST.
Nick Lodolo (8-8, 3.44 ERA) will start on the mound for the Reds, up against Braxton Ashcraft (4-3, 2.62 ERA) for the Pirates.
This article features Stats Insider's prediction and tips for the Reds vs Pirates game, along with the latest betting odds in Australia.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the result of Friday's Cincinnati vs Pittsburgh MLB game 10,000 times.
Our leading predictive analytics model gives the Reds a 59% chance of defeating the Pirates at Great American Ball Park.
Reds vs Pirates: Odds
The current betting odds in Australia for Friday's MLB game at Great American Ball Park are listed below:
- Head to Head: Reds $1.59, Pirates $2.45
- Line: Reds -1.5 ($2.25), Pirates +1.5 ($1.67)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.59 and the Pirates at $2.45.
The Reds are 1.5-run favourites against the Pirates, with odds of $2.25 available at TAB.
For the underdog Pirates (+1.5) to cover the line, TAB offers odds of $1.67.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Pirates (+1.5) are predicted to cover the line 59% of the time, while the 8-run over/under is expected to stay under 51% of the time.
Reds vs Pirates: Best Bets
- Head to Head: Pittsburgh at $2.45 with TAB
- Line: Pirates +1.5 at $1.67 with TAB
- Total Runs: Over 8 at $1.91 with TAB
Stats Insider's Reds vs Pirates predictions are based on complex simulations and betting experience to help you place more informed bets with your chosen online bookie.
While the Reds have a higher chance of winning the game, betting on the Pirates to win is our recommended option due to the 1.2% edge identified when comparing our data-led probabilities to the odds currently on offer.
Taking advantage of the edges seen here at Stats Insider is crucial to achieving long-term profitability.
Furthermore, despite the Under being more likely to hit in this game, Over 8 is our best bet because of the better odds ($1.91) that are available from TAB.
Reds vs Pirates: Prediction
Stats Insider provides full betting coverage of the Cincinnati vs Pittsburgh game on Friday, including data-driven predictions and top betting tips.
Our model updates regularly, so keep checking this article for the latest betting predictions before the Cincinnati vs Pittsburgh match-up.
As always, see our Best Bets for betting tips on every MLB game, plus predictions for a wide range of other sports.
Reds vs Pirates: Essential Details
The game between the Reds and Pirates at Great American Ball Park is scheduled to start at 2:40am AEST on Friday.
- Teams: Cincinnati Reds vs Pittsburgh Pirates
- Date: Friday 26 September 2025
- Time: 2:40am AEST
- Venue: Great American Ball Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cincinnati vs Pittsburgh predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures probabilities for the MLB.
