Reds vs Cubs Prediction and MLB Tips - 22 September 2025
Last updated: Sep 21, 2025, 6:50PM | Published: Sep 20, 2025, 6:30PM
The Cincinnati Reds will sqaure off with the Chicago Cubs in Game of the League Series at Great American Ball Park on Monday, commencing at 3:40am AEST.
Andrew Abbott (9-7, 2.88 ERA) will start on the mound for the Reds, while the Cubs are going with Jameson Taillon (10-6, 3.93 ERA).
This article features Stats Insider's prediction and tips for the Reds vs Cubs game, along with the latest betting odds in Australia.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the result of Monday's Cincinnati vs Cubs MLB match-up 10,000 times.
Our independent predictive analytics model gives the Reds a 51% chance of defeating the Cubs at Great American Ball Park.
Reds vs Cubs: Odds
The latest betting odds in Australia for Monday's MLB game at Great American Ball Park are shown below:
- Head to Head: Reds $1.83, Cubs $2.00
- Line: Reds -1.5 ($2.70), Cubs +1.5 ($1.49)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.83 and the Cubs at $2.00.
The Reds are 1.5-run favourites against the Cubs, with odds of $2.70 available at TAB.
For the underdog Cubs (+1.5) to cover the line, TAB offers odds of $1.49.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cubs (+1.5) are predicted to cover the line 66% of the time, while the 9-run over/under is expected to stay under 52% of the time.
Reds vs Cubs: Best Bets
- Head to Head: Cubs at $2.00 with TAB
- Line: Cubs +1.5 at $1.49 with TAB
- Total Runs: Over 9 at $1.91 with TAB
Our Reds vs Cubs betting tips are based on market-leading simulations and gambling experience to give you the best possible advice every day of the year.
While the Reds have a higher chance of winning the game, betting on the Cubs to win is our recommended option because of the 1.0% edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published here at Stats Insider is crucial to being profitable in the long run.
Furthermore, despite the Under being more likely to hit in this game, Over 9 is our best bet because of the better odds ($1.91) that are available from TAB.
Reds vs Cubs: Prediction
Stats Insider provides full betting coverage of the Cincinnati vs Cubs game on Monday, including data-driven predictions and the best betting tips.
Our model updates frequently, so bookmark this page for the latest betting predictions before the Cincinnati vs Cubs match-up.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Reds vs Cubs: Essential Details
The match-up between the Reds and Cubs at Great American Ball Park is scheduled to start at 3:40am AEST on Monday.
- Teams: Cincinnati Reds vs Chicago Cubs
- Date: Monday 22 September 2025
- Time: 3:40am AEST
- Venue: Great American Ball Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cincinnati vs Cubs predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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