Reds vs Cubs Prediction and MLB Tips - 21 September 2026
Last updated: Sep 20, 2026, 7:51AM | Published: Sep 20, 2026, 6:32AM
The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Monday, beginning at 3:40am AEST.
Rhett Lowder (6-11, 5.79 ERA) will get the ball for the Reds, while the Cubs are going with David Peterson (8-8, 5.11 ERA).
This article features Stats Insider's top betting tips for the Reds vs Cubs game, as well as the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Cincinnati vs Cubs MLB game 10,000 times.
Our leading predictive analytics model currently gives the Cubs a 56% chance of beating the Reds at Great American Ball Park.
Reds vs Cubs: Odds
The latest betting odds in Australia for Monday's MLB game at Great American Ball Park are shown below:
- Head to Head: Reds $2.30, Cubs $1.65
- Line: Reds +1.5 ($1.80), Cubs -1.5 ($2.04)
- Total (Over/Under 10 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $2.30 and the Cubs at $1.65.
The Reds are listed as 1.5-run underdogs against the Cubs, with odds of $1.80 available at TAB.
For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.04.
The over/under for total runs scored is set at 10 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Reds (+1.5) are predicted to cover the line 55% of the time, while the 10-run over/under is expected to is considered an equal 50-50 chance of hitting.
Reds vs Cubs: Betting Tips
- Head to Head: Cincinnati at $2.30 with TAB
- Line: Reds +1.5 at $1.80 with TAB
- Total Runs: Over 10 at $1.91 with TAB
Stats Insider's Reds vs Cubs betting tips are based on market-leading modelling and wagering experience to give you the best possible advice around the clock.
While the Cubs have a higher chance of winning the game, betting on the Reds to win is our recommended option because of the 1.8% edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen here at Stats Insider is one of the keys to being a profitable punter in the long run.
Reds vs Cubs: Prediction
Stats Insider provides full betting coverage of the Cincinnati vs Cubs game on Monday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so keep checking this article for the latest betting predictions before the Cincinnati vs Cubs match-up.
As always, see Stats Insider's Best Bets to get the best tips on every MLB game, plus predictions for a wide range of other sports.
Reds vs Cubs: Essential Details
The game between the Reds and Cubs at Great American Ball Park is scheduled to begin at 3:40am AEST on Monday.
- Teams: Cincinnati Reds vs Chicago Cubs
- Date: Monday 21 September 2026
- Time: 3:40am AEST
- Venue: Great American Ball Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cincinnati vs Cubs predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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