Reds vs Cubs Prediction and MLB Tips - 21 September 2025
Last updated: Sep 20, 2025, 10:42PM | Published: Sep 19, 2025, 6:30PM
The Cincinnati Reds will sqaure off with the Chicago Cubs in Game of the League Series at Great American Ball Park on Sunday, starting at 8:40am AEST.
Zack Littell (9-8, 3.86 ERA) will start on the mound for the Reds, while the Cubs will counter with Javier Assad (3-1, 4.23 ERA).
This article features Stats Insider's prediction and tips for the Reds vs Cubs game, as well as the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the outcome of Sunday's Cincinnati vs Cubs MLB game 10,000 times.
Our proven predictive analytics model gives the Cubs a 51% chance of defeating the Reds at Great American Ball Park.
Reds vs Cubs: Odds
The current betting odds in Australia for Sunday's MLB game at Great American Ball Park are shown here:
- Head to Head: Reds $1.87, Cubs $1.95
- Line: Reds -1.5 ($2.79), Cubs +1.5 ($1.46)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.87 and the Cubs at $1.95.
The Reds are listed as 1.5-run favourites against the Cubs, with odds of $2.79 available at TAB.
For the underdog Cubs (+1.5) to cover the line, TAB offers odds of $1.46.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cubs (+1.5) are predicted to cover the line 68% of the time, while the 9-run over/under is expected to go over 51% of the time.
Reds vs Cubs: Betting Tips
- Head to Head: Cubs at $1.95 with TAB
- Line: Cubs +1.5 at $1.46 with TAB
- Total Runs: Over 9 at $1.91 with TAB
Our Reds vs Cubs predictions are based on detailed simulations and betting experience to help you place smarter bets with your chosen online bookie.
Reds vs Cubs: Prediction
Stats Insider provides full betting coverage of the Cincinnati vs Cubs game on Sunday, including data-driven predictions and free tips.
Our model updates regularly, so bookmark this article for the latest betting analysis before the Cincinnati vs Cubs game.
As always, see Stats Insider's Best Bets to get betting tips for every MLB game, plus predictions for a wide range of other sports.
Reds vs Cubs: Essential Details
The game between the Reds and Cubs at Great American Ball Park is scheduled to begin at 8:40am AEST on Sunday.
- Teams: Cincinnati Reds vs Chicago Cubs
- Date: Sunday 21 September 2025
- Time: 8:40am AEST
- Venue: Great American Ball Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cincinnati vs Cubs predictions have been made based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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