Reds vs Cubs Prediction and MLB Tips - 20 September 2025
Last updated: Sep 19, 2025, 9:15AM | Published: Sep 18, 2025, 8:30PM
The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Saturday, starting at 8:40am AEST.
The Reds will send Nick Lodolo (8-8, 3.30 ERA) to the mound, while the Cubs will counter with Shota Imanaga (9-7, 3.29 ERA).
This article features Stats Insider's top betting tips for the Reds vs Cubs game, along with the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the outcome of Saturday's Cincinnati vs Cubs MLB game 10,000 times.
Our proven predictive analytics model gives the Cubs a 52% chance of defeating the Reds at Great American Ball Park.
Reds vs Cubs: Odds
The latest betting odds in Australia for Saturday's MLB game at Great American Ball Park are listed here:
- Head to Head: Reds $2.05, Cubs $1.80
- Line: Reds +1.5 ($1.61), Cubs -1.5 ($2.40)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $2.05 and the Cubs at $1.80.
The Reds are listed as 1.5-run underdogs against the Cubs, with odds of $1.61 available at TAB.
For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.40.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Reds (+1.5) are predicted to cover the line 61% of the time, while the 8.5-run over/under is expected to is considered an equal 50-50 chance of hitting.
Reds vs Cubs: Best Bets
- Head to Head: Cincinnati at $2.05 with TAB
- Line: Reds +1.5 at $1.61 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
These Reds vs Cubs betting tips are based on detailed simulations and wagering experience to help you place more informed bets with your chosen online bookie.
While the Cubs have a higher chance of winning the game, betting on the Reds to win is our preferred option due to the 1.2% edge found when comparing our data-driven probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is pivotal to achieving long-term success as a punter.
Reds vs Cubs: Prediction
Stats Insider provides full betting coverage of the Cincinnati vs Cubs game on Saturday, including data-driven predictions and computer tips.
Remember, our model updates regularly, so keep checking this page for the latest betting predictions before the Cincinnati vs Cubs game.
As always, see Stats Insider's Best Bets for the best tips for every MLB game, as well as predictions for a wide range of other sports.
Reds vs Cubs: Essential Details
The game between the Reds and Cubs at Great American Ball Park is scheduled to begin at 8:40am AEST on Saturday.
- Teams: Cincinnati Reds vs Chicago Cubs
- Date: Saturday 20 September 2025
- Time: 8:40am AEST
- Venue: Great American Ball Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cincinnati vs Cubs predictions are based on 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our MLB predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures probabilities for the MLB.
