Reds vs Cubs Prediction and MLB Tips - 20 September 2025
Last updated: Sep 19, 2025, 10:42PM | Published: Sep 18, 2025, 8:30PM
The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Saturday, starting at 8:40am AEST.
The Reds will have Nick Lodolo (8-8, 3.30 ERA) start, pitting him against Shota Imanaga (9-7, 3.29 ERA) for the Cubs.
This article features Stats Insider's prediction and tips for the Reds vs Cubs game, plus the latest betting odds in Australia.
Who Will Win?
Using advanced machine learning and data, Stats Insider has simulated the outcome of Saturday's Cincinnati vs Cubs MLB match-up 10,000 times.
Our proven predictive analytics model is currently unable to split the two teams, giving both the Reds and the Cubs an equal 50% chance of winning the game.
Reds vs Cubs: Odds
The latest betting odds in Australia for Saturday's MLB game at Great American Ball Park are listed here:
- Head to Head: Reds $1.95, Cubs $1.87
- Line: Reds +1.5 ($1.59), Cubs -1.5 ($2.45)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.95 and the Cubs at $1.87.
The Reds are listed as 1.5-run underdogs against the Cubs, with odds of $1.59 available at TAB.
For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.45.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Reds (+1.5) are predicted to cover the line 62% of the time, while the 8-run over/under is expected to go over 53% of the time.
Reds vs Cubs: Betting Tips
- Head to Head: Cincinnati at $1.95 with TAB
- Line: Reds +1.5 at $1.59 with TAB
- Total Runs: Over 8 at $1.91 with TAB
Today's Reds vs Cubs predictions are based on world-class modelling and gambling expertise to provide you with the best possible advice 24/7/365.
Reds vs Cubs: Prediction
Stats Insider provides full coverage of the Cincinnati vs Cubs game on Saturday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so keep checking this article for the latest betting predictions before the Cincinnati vs Cubs game.
As always, see Stats Insider's Best Bets to get the best tips for every MLB game, plus predictions for a wide range of other sports.
Reds vs Cubs: Essential Details
The match-up between the Reds and Cubs at Great American Ball Park is scheduled to commence at 8:40am AEST on Saturday.
- Teams: Cincinnati Reds vs Chicago Cubs
- Date: Saturday 20 September 2025
- Time: 8:40am AEST
- Venue: Great American Ball Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cincinnati vs Cubs predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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