Reds vs Cubs Prediction and MLB Tips - 19 September 2025
Last updated: Sep 18, 2025, 11:15PM | Published: Sep 18, 2025, 5:30AM
The Cincinnati Reds will face the Chicago Cubs in MLB action at Great American Ball Park on Friday, commencing at 9:15am AEST.
The Reds will send Hunter Greene (6-4, 3.01 ERA) to the mound, up against Colin Rea (10-6, 4.23 ERA) for the Cubs.
This article features Stats Insider's best betting tips for the Reds vs Cubs game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Friday's Cincinnati vs Cubs MLB game 10,000 times.
Our leading predictive analytics model gives the Reds a 56% chance of defeating the Cubs at Great American Ball Park.
Reds vs Cubs: Odds
The latest betting odds in Australia for Friday's MLB game at Great American Ball Park are shown below:
- Head to Head: Reds $1.67, Cubs $2.25
- Line: Reds -1.5 ($2.45), Cubs +1.5 ($1.59)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.67 and the Cubs at $2.25.
The Reds are 1.5-run favourites against the Cubs, with odds of $2.45 available at TAB.
For the underdog Cubs (+1.5) to cover the line, TAB offers odds of $1.59.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cubs (+1.5) are predicted to cover the line 62% of the time, while the 8.5-run over/under is expected to stay under 51% of the time.
Reds vs Cubs: Betting Tips
- Head to Head: Cubs at $2.25 with TAB
- Line: Cubs +1.5 at $1.59 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Our Reds vs Cubs best bets are based on market-leading simulations and gambling experience to help you place more informed bets with your chosen online bookie.
While the Reds have a higher chance of winning the game, betting on the Cubs to win is our recommended option because of the 1.2% edge found when comparing our data-driven probabilities to the odds currently on offer.
Making use of the edges seen here at Stats Insider is pivotal to achieving long-term success as a sports bettor.
Furthermore, despite the Under being more likely to hit in this game, Over 8.5 is our best bet due to the better odds ($1.91) that are available from TAB.
Reds vs Cubs: Prediction
Stats Insider provides full coverage of the Cincinnati vs Cubs game on Friday, including data-driven predictions and top betting tips.
Our model updates regularly, so keep checking this page for the latest betting analysis before the Cincinnati vs Cubs match-up.
As always, see our Best Bets to get the best tips for every MLB game, plus predictions for a wide range of other sports.
Reds vs Cubs: Essential Details
The match-up between the Reds and Cubs at Great American Ball Park is scheduled to commence at 9:15am AEST on Friday.
- Teams: Cincinnati Reds vs Chicago Cubs
- Date: Friday 19 September 2025
- Time: 9:15am AEST
- Venue: Great American Ball Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cincinnati vs Cubs predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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