Reds vs Cardinals Prediction and MLB Tips - 21 August 2026
Last updated: Aug 19, 2026, 11:44PM | Published: Aug 19, 2026, 5:45PM
The Cincinnati Reds will take on the St. Louis Cardinals in MLB action at Great American Ball Park on Friday, beginning at 2:40am AEST.
Brady Singer (5-11, 4.66 ERA) will be on the bump for the Reds, pitting him against Michael McGreevy (5-9, 3.48 ERA) for the Cardinals.
This article features Stats Insider's prediction and tips for the Reds vs Cardinals game, plus the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Friday's Cincinnati vs St. Louis MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Reds a 51% chance of beating the Cardinals at Great American Ball Park.
Reds vs Cardinals: Odds
The latest betting odds in Australia for Friday's MLB game at Great American Ball Park are listed below:
- Head to Head: Reds $1.95, Cardinals $1.87
- Line: Reds +1.5 ($1.56), Cardinals -1.5 ($2.50)
- Total (Over/Under 9 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.95 and the Cardinals at $1.87.
The Reds are 1.5-run underdogs against the Cardinals, with odds of $1.56 available at TAB.
For the favourite Cardinals (-1.5) to cover the line, TAB offers odds of $2.50.
The over/under for total runs scored is set at 9 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Reds (+1.5) are predicted to cover the line 63% of the time, while the 9-run over/under is expected to go over 52% of the time.
Reds vs Cardinals: Best Bets
- Head to Head: Cincinnati at $1.95 with TAB
- Line: Reds +1.5 at $1.56 with TAB
- Total Runs: Over 9 at $1.91 with TAB
These Reds vs Cardinals predictions are based on market-leading simulations and betting experience to help you place smarter bets with your chosen online bookie.
Reds vs Cardinals: Prediction
Stats Insider provides full coverage of the Cincinnati vs St. Louis game on Friday, including data-driven predictions and computer tips.
Our model updates regularly, so bookmark this article for the latest betting tips before the Cincinnati vs St. Louis match-up.
As always, see Stats Insider's Best Bets to get betting tips for every MLB game, as well as predictions for a wide range of other sports.
Reds vs Cardinals: Essential Details
The match-up between the Reds and Cardinals at Great American Ball Park is scheduled to start at 2:40am AEST on Friday.
- Teams: Cincinnati Reds vs St. Louis Cardinals
- Date: Friday 21 August 2026
- Time: 2:40am AEST
- Venue: Great American Ball Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Cincinnati vs St. Louis predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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