Reds vs Cardinals Prediction and MLB Tips - 21 August 2026
Last updated: Aug 20, 2026, 4:40PM | Published: Aug 19, 2026, 5:45PM
The Cincinnati Reds will take on the St. Louis Cardinals in MLB action at Great American Ball Park on Friday, starting at 2:40am AEST.
The Reds will have Brady Singer (5-11, 4.66 ERA) start, while the Cardinals will counter with Michael McGreevy (5-9, 3.48 ERA).
This article features Stats Insider's best betting tips for the Reds vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the result of Friday's Cincinnati vs St. Louis MLB match-up 10,000 times.
Our independent predictive analytics model gives the Reds a 51% chance of beating the Cardinals at Great American Ball Park.
Reds vs Cardinals: Odds
The current betting odds in Australia for Friday's MLB game at Great American Ball Park are listed below:
- Head to Head: Reds $1.98, Cardinals $1.94
- Line: Reds +1.5 ($1.59), Cardinals -1.5 ($2.40)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Reds at $1.98 and the Cardinals at $1.94.
The Reds are listed as 1.5-run underdogs against the Cardinals, with odds of $1.59 available at TAB.
For the favourite Cardinals (-1.5) to cover the line, TAB offers odds of $2.40.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Reds (+1.5) are predicted to cover the line 62% of the time, while the 8.5-run over/under is expected to go over 55% of the time.
Reds vs Cardinals: Best Bets
- Head to Head: Cincinnati at $1.98 with TAB
- Line: Reds +1.5 at $1.59 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Our Reds vs Cardinals best bets are based on complex simulations and wagering experience to help you place smarter bets with your chosen online bookie.
Reds vs Cardinals: Prediction
Stats Insider provides full coverage of the Cincinnati vs St. Louis game on Friday, including data-driven predictions and free betting tips.
Our model updates frequently, so keep checking this article for the latest betting analysis before the Cincinnati vs St. Louis match-up.
As always, see our Best Bets to get betting tips on every MLB game, plus predictions for a wide range of other sports.
Reds vs Cardinals: Essential Details
The match-up between the Reds and Cardinals at Great American Ball Park is scheduled to start at 2:40am AEST on Friday.
- Teams: Cincinnati Reds vs St. Louis Cardinals
- Date: Friday 21 August 2026
- Time: 2:40am AEST
- Venue: Great American Ball Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Cincinnati vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our MLB predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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