Red Sox vs Yankees Prediction and MLB Tips - 22 April 2026
Last updated: Apr 21, 2026, 2:50PM | Published: Apr 20, 2026, 5:28PM
The Boston Red Sox will face the New York Yankees in MLB action at Fenway Park on Wednesday, beginning at 8:45am AEST.
Connelly Early (1-0, 2.29 ERA) will get the ball for the Red Sox, while the Yankees are going with Luis Gil (0-1, 7.00 ERA).
This article features Stats Insider's prediction and tips for the Red Sox vs Yankees game, plus the latest betting odds in Australia.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Wednesday's Boston vs NY Yankees MLB game 10,000 times.
Our leading predictive analytics model gives the Red Sox a 54% chance of defeating the Yankees at Fenway Park.
Red Sox vs Yankees: Odds
The current betting odds in Australia for Wednesday's MLB game at Fenway Park are shown below:
- Head to Head: Red Sox $1.83, Yankees $2.00
- Line: Red Sox +1.5 ($1.56), Yankees -1.5 ($2.50)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Red Sox at $1.83 and the Yankees at $2.00.
The Red Sox are listed as 1.5-run underdogs against the Yankees, with odds of $1.56 available at TAB.
For the favourite Yankees (-1.5) to cover the line, TAB offers odds of $2.50.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Red Sox (+1.5) are predicted to cover the line 65% of the time, while the 8.5-run over/under is expected to is considered an equal 50-50 chance of hitting.
Red Sox vs Yankees: Betting Tips
- Head to Head: Boston at $1.83 with TAB
- Line: Red Sox +1.5 at $1.56 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Stats Insider's Red Sox vs Yankees predictions are based on complex simulations and gambling experience to help you place better bets with your chosen online bookie.
Red Sox vs Yankees: Prediction
Stats Insider provides full coverage of the Boston vs NY Yankees game on Wednesday, including data-driven predictions and the best betting tips.
Remember, our model updates regularly, so bookmark this page for the latest betting predictions before the Boston vs NY Yankees game.
As always, see our Best Bets for betting tips on every MLB game, plus predictions for a wide range of other sports.
Red Sox vs Yankees: Essential Details
The game between the Red Sox and Yankees at Fenway Park is scheduled to commence at 8:45am AEST on Wednesday.
- Teams: Boston Red Sox vs New York Yankees
- Date: Wednesday 22 April 2026
- Time: 8:45am AEST
- Venue: Fenway Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Boston vs NY Yankees predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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