Red Sox vs Yankees Prediction and MLB Tips - 22 April 2026
Last updated: Apr 21, 2026, 10:45PM | Published: Apr 20, 2026, 5:28PM
The Boston Red Sox will take on the New York Yankees in MLB action at Fenway Park on Wednesday, starting at 8:45am AEST.
The Red Sox will have Connelly Early (1-0, 2.29 ERA) start, pitting him against Luis Gil (0-1, 7.00 ERA) for the Yankees.
This article features Stats Insider's prediction and tips for the Red Sox vs Yankees game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Wednesday's Boston vs NY Yankees MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Red Sox a 55% chance of winning against the Yankees at Fenway Park.
Red Sox vs Yankees: Odds
The current betting odds in Australia for Wednesday's MLB game at Fenway Park are shown here:
- Head to Head: Red Sox $1.77, Yankees $2.10
- Line: Red Sox -1.5 ($2.65), Yankees +1.5 ($1.50)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Red Sox at $1.77 and the Yankees at $2.10.
The Red Sox are 1.5-run favourites against the Yankees, with odds of $2.65 available at TAB.
For the underdog Yankees (+1.5) to cover the line, TAB offers odds of $1.50.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Yankees (+1.5) are predicted to cover the line 62% of the time, while the 8.5-run over/under is expected to is considered an equal 50-50 chance of hitting.
Red Sox vs Yankees: Best Bets
- Head to Head: Boston at $1.77 with TAB
- Line: Red Sox -1.5 at $2.65 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Our Red Sox vs Yankees best bets are based on detailed simulations and gambling intelligence to help you place more informed bets with your chosen online bookie.
Even though the Yankees are more likely to cover the line, our best bet of Red Sox -1.5 is based on the chance of that happening, as projected by our predictive analytics model, and the top odds available.
Red Sox vs Yankees: Prediction
Stats Insider provides full coverage of the Boston vs NY Yankees game on Wednesday, including data-driven predictions and live win probabilitiestips.
Remember, our model updates frequently, so refresh this page for the latest betting predictions before the Boston vs NY Yankees match-up.
As always, see our Best Bets for the best tips on every MLB game, as well as predictions for a wide range of other sports.
Red Sox vs Yankees: Essential Details
The game between the Red Sox and Yankees at Fenway Park is scheduled to commence at 8:45am AEST on Wednesday.
- Teams: Boston Red Sox vs New York Yankees
- Date: Wednesday 22 April 2026
- Time: 8:45am AEST
- Venue: Fenway Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Boston vs NY Yankees predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's important to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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