Rays vs Red Sox Prediction and MLB Tips - 22 September 2025

The Tampa Bay Rays will face the Boston Red Sox in Game of the League Series at George M. Steinbrenner Field on Monday, starting at 9:35am AEST.

The Rays will have Joe Boyle (1-3, 4.64 ERA) start, up against Connelly Early (1-0, 0.87 ERA) for the Red Sox.

This article features Stats Insider's top betting tips for the Rays vs Red Sox game, as well as the latest betting odds in Australia.

Who Will Win?

Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Monday's Tampa Bay vs Boston MLB game 10,000 times.

Our proven predictive analytics model gives the Red Sox a 54% chance of defeating the Rays at George M. Steinbrenner Field.

Rays vs Red Sox: Odds

The current betting odds in Australia for Monday's MLB game at George M. Steinbrenner Field are shown here:

• Head to Head: Rays $2.10, Red Sox $1.77
• Line: Rays +1.5 ($1.65), Red Sox -1.5 ($2.29)
• Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, the bookmakers currently have the Rays at $2.10 and the Red Sox at $1.77.

The Rays are 1.5-run underdogs against the Red Sox, with odds of $1.65 available at TAB.

For the favourite Red Sox (-1.5) to cover the line, TAB offers odds of $2.29.

The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Rays (+1.5) are predicted to cover the line 59% of the time, while the 7.5-run over/under is expected to stay under 51% of the time.

Rays vs Red Sox: Betting Tips

• Head to Head: Tampa Bay at $2.10 with TAB
• Line: Rays +1.5 at $1.65 with TAB
• Total Runs: Over 7.5 at $1.91 with TAB

Today's Rays vs Red Sox best bets are based on complex modelling and betting experience to give you the best possible advice every day of the year.

While the Red Sox have a higher chance of winning the game, betting on the Rays to win is our recommended option due to the edge found when comparing our data-driven probabilities to the odds currently available.

Taking advantage of the edges published here at Stats Insider is pivotal to achieving long-term profitability.

Furthermore, despite the Under being more likely to hit in this game, Over 7.5 is our best bet because of the better odds ($1.91) that are available from TAB.

Rays vs Red Sox: Prediction

Stats Insider provides full coverage of the Tampa Bay vs Boston game on Monday, including data-driven predictions and free betting tips.

Our model updates regularly, so bookmark this page for the latest betting predictions before the Tampa Bay vs Boston match-up.

As always, see our Best Bets to get the best tips on every MLB game, as well as predictions for a wide range of other sports.

Rays vs Red Sox: Essential Details

The game between the Rays and Red Sox at George M. Steinbrenner Field is scheduled to begin at 9:35am AEST on Monday.

• Teams: Tampa Bay Rays vs Boston Red Sox
• Date: Monday 22 September 2025
• Time: 9:35am AEST
• Venue: George M. Steinbrenner Field

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our Tampa Bay vs Boston predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you choose to use our MLB predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on MLB

Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures odds for the MLB.