Rays vs Guardians Prediction and MLB Tips - 5 September 2025
Last updated: Sep 4, 2025, 11:35PM | Published: Sep 4, 2025, 6:57PM
The Tampa Bay Rays will take on the Cleveland Guardians in MLB action at George M. Steinbrenner Field on Friday, starting at 9:35am AEST.
Ryan Pepiot (10-10, 3.70 ERA) will start on the mound for the Rays, up against Logan Allen (7-10, 4.42 ERA) for the Guardians.
This article features Stats Insider's prediction and tips for the Rays vs Guardians game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the outcome of Friday's Tampa Bay vs Cleveland MLB game 10,000 times.
Our independent predictive analytics model gives the Rays a 60% chance of beating the Guardians at George M. Steinbrenner Field.
Rays vs Guardians: Odds
The latest betting odds in Australia for Friday's MLB game at George M. Steinbrenner Field are shown below:
- Head to Head: Rays $1.56, Guardians $2.50
- Line: Rays -1.5 ($2.20), Guardians +1.5 ($1.72)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Rays at $1.56 and the Guardians at $2.50.
The Rays are 1.5-run favourites against the Guardians, with odds of $2.20 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.72.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Guardians (+1.5) are predicted to cover the line 59% of the time, while the 8.5-run over/under is expected to stay under 56% of the time.
Rays vs Guardians: Best Bets
- Head to Head: Cleveland at $2.50 with TAB
- Line: Guardians +1.5 at $1.72 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Our Rays vs Guardians best bets are based on world-class simulations and gambling intelligence to bring you the best possible advice around the clock.
While the Rays have a higher chance of winning the game, betting on the Guardians to win is our preferred option because of the 1.5% edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges seen here at Stats Insider is crucial to achieving long-term success as a sports bettor.
Rays vs Guardians: Prediction
Stats Insider provides full coverage of the Tampa Bay vs Cleveland game on Friday, including data-driven predictions and live scorestips.
Our model updates frequently, so bookmark this article for the latest betting analysis before the Tampa Bay vs Cleveland game.
As always, see Stats Insider's Best Bets for the best tips for every MLB game, as well as predictions for a wide range of other sports.
Rays vs Guardians: Essential Details
The game between the Rays and Guardians at George M. Steinbrenner Field is scheduled to commence at 9:35am AEST on Friday.
- Teams: Tampa Bay Rays vs Cleveland Guardians
- Date: Friday 5 September 2025
- Time: 9:35am AEST
- Venue: George M. Steinbrenner Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Tampa Bay vs Cleveland predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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