Rays vs Guardians Prediction and MLB Tips - 5 September 2025
Last updated: Sep 4, 2025, 6:15PM | Published: Sep 4, 2025, 12:30AM
The Tampa Bay Rays will face the Cleveland Guardians in MLB action at George M. Steinbrenner Field on Friday, starting at 9:35am AEST.
Ryan Pepiot (10-10, 3.70 ERA) will start on the mound for the Rays, while the Guardians will counter with Logan Allen (7-10, 4.42 ERA).
This article features Stats Insider's top betting tips for the Rays vs Guardians game, along with the latest betting odds in Australia.
Who Will Win?
Based on advanced computer power and data, Stats Insider has simulated the outcome of Friday's Tampa Bay vs Cleveland MLB game 10,000 times.
Our leading predictive analytics model currently gives the Rays a 59% chance of defeating the Guardians at George M. Steinbrenner Field.
Rays vs Guardians: Odds
The latest betting odds in Australia for Friday's MLB game at George M. Steinbrenner Field are listed below:
- Head to Head: Rays $1.59, Guardians $2.45
- Line: Rays -1.5 ($2.25), Guardians +1.5 ($1.67)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Rays at $1.59 and the Guardians at $2.45.
The Rays are 1.5-run favourites against the Guardians, with odds of $2.25 available at TAB.
For the underdog Guardians (+1.5) to cover the line, TAB offers odds of $1.67.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Guardians (+1.5) are predicted to cover the line 60% of the time, while the 8.5-run over/under is expected to stay under 54% of the time.
Rays vs Guardians: Betting Tips
- Head to Head: Cleveland at $2.45 with TAB
- Line: Guardians +1.5 at $1.67 with TAB
- Total Runs: Under 8.5 at $1.91 with TAB
Our Rays vs Guardians best bets are based on world-class modelling and wagering intelligence to provide you with the best possible advice every day of the year.
While the Rays have a higher chance of winning the game, betting on the Guardians to win is our preferred option due to the 1.8% edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen on Stats Insider is pivotal to achieving long-term success as a sports bettor.
Rays vs Guardians: Prediction
Stats Insider provides full betting coverage of the Tampa Bay vs Cleveland game on Friday, including data-driven predictions and live win probabilitiestips.
Our model updates regularly, so bookmark this article for the latest betting tips before the Tampa Bay vs Cleveland game.
As always, see Stats Insider's Best Bets for the best tips for every MLB game, plus predictions for a wide range of other sports.
Rays vs Guardians: Essential Details
The game between the Rays and Guardians at George M. Steinbrenner Field is scheduled to begin at 9:35am AEST on Friday.
- Teams: Tampa Bay Rays vs Cleveland Guardians
- Date: Friday 5 September 2025
- Time: 9:35am AEST
- Venue: George M. Steinbrenner Field
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Tampa Bay vs Cleveland predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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