Rams vs Colts Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 28, 2025, 8:01PM | Published: Sep 21, 2025, 4:02AM
The Los Angeles Rams will face the Indianapolis Colts in NFL Week 4 action at SoFi Stadium on Monday, starting at 6:05am AEST.
This article features Stats Insider's top betting tips for the Rams vs Colts game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Monday's LA Rams vs Indianapolis NFL game 10,000 times.
Our independent predictive analytics model currently gives the Rams a 60% chance of defeating the Colts in Week 4 of the NFL season.
Rams vs Colts: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at SoFi Stadium are listed below:
- Head to Head: Rams $1.54, Colts $2.55
- Line: Rams -3.5 ($1.91), Colts +3.5 ($1.91)
- Total (Over/Under 49.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Rams at $1.54 and the Colts at $2.55.
The Rams are listed as 3.5-point favourites against the Colts, with odds of $1.91 available at Bet365.
For the underdog Colts (+3.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Colts (+3.5) are predicted to cover the line 59% of the time, while the 49.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Rams vs Colts: Betting Tips
- Head to Head: Indianapolis at $2.55 with Bet365
- Line: Colts +3.5 at $1.91 with Bet365
- Total Points: Under 49.5 at $1.91 with Bet365
When you see a 🔥, that means you've found one of our best tips for today across any sport.
Today's Rams vs Colts betting tips are based on market-leading modelling and wagering intelligence to give you the best possible advice around the clock.
While the Rams have a higher chance of winning the game, betting on the Colts to win is our recommended option because of the edge identified when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is crucial to achieving long-term success as a sports bettor.
Rams vs Colts: Prediction
Stats Insider's predicted final score for Rams vs Colts at SoFi Stadium in Week 4 is the Rams winning 26-23.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the LA Rams vs Indianapolis game in Week 4, including data-driven predictions and top betting tips.
For in-depth analysis from US experts,, check out Dimers' detailed Rams vs Colts prediction.
18+. Odds correct at time of publishing and subject to change.Rams vs Colts: TD Scorer Tips
Who will score the first touchdown in Rams vs Colts? The data is in.
According to Stats Insider, Indianapolis' Jonathan Taylor is the most likely player to score the first touchdown in Rams vs Colts.
Taylor has a 14.8% chance of getting in for six first at SoFi Stadium, while the Colts RB has a 57.8% chance of scoring an anytime touchdown.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Rams First TD Tips
- Kyren Williams: 14.7% probability
- Davante Adams: 9.0% probability
- Puka Nacua: 8.8% probability
- Blake Corum: 4.0% probability
- Tyler Higbee: 3.0% probability
Colts First TD Tips
- Jonathan Taylor: 14.8% probability
- Daniel Jones: 6.3% probability
- Tyler Warren: 5.5% probability
- Michael Pittman: 4.6% probability
- Josh Downs: 3.7% probability
Anytime Touchdown Scorer Tips
Rams Anytime TD Tips
- Kyren Williams: 57.5% probability
- Davante Adams: 40.8% probability
- Puka Nacua: 39.9% probability
- Blake Corum: 20.7% probability
- Tyler Higbee: 16.1% probability
Colts Anytime TD Tips
- Jonathan Taylor: 57.8% probability
- Daniel Jones: 30.8% probability
- Tyler Warren: 27.4% probability
- Michael Pittman: 23.7% probability
- Josh Downs: 19.3% probability
Rams-Colts Projected Player Stats
Of the starting quarterbacks, the Rams' Matthew Stafford is projected for 256 passing yards, while the Colts' Daniel Jones is expected to throw for 224 yards.
Rams Starting QB
- Matthew Stafford: 256 projected passing yards
Colts Starting QB
- Daniel Jones: 224 projected passing yards
Rams Rushing Yards
- Kyren Williams: 75 projected yards
- Blake Corum: 25 projected yards
- Puka Nacua: 5 projected yards
Colts Rushing Yards
- Jonathan Taylor: 84 projected yards
- Daniel Jones: 26 projected yards
- DJ Giddens: 6 projected yards
Rams Receiving Yards
- Puka Nacua: 95 projected yards
- Davante Adams: 68 projected yards
- Jordan Whittington: 22 projected yards
- Tyler Higbee: 19 projected yards
- Tutu Atwell: 19 projected yards
Colts Receiving Yards
- Michael Pittman: 59 projected yards
- Tyler Warren: 52 projected yards
- Josh Downs: 45 projected yards
- Adonai Mitchell: 37 projected yards
- Jonathan Taylor: 18 projected yards
Our model updates frequently, so bookmark this page for the latest betting predictions before the LA Rams vs Indianapolis game.
As always, see our Best Bets for the best tips on every NFL game, as well as predictions for a wide range of other sports.
Rams vs Colts: Week 4 Essential Details
The NFL Week 4 game between the Rams and Colts at SoFi Stadium is scheduled to commence at 6:05am AEST on Monday.
- Teams: Los Angeles Rams vs Indianapolis Colts
- Date: Monday 29 September 2025
- Time: 6:05am AEST
- Venue: SoFi Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our LA Rams vs Indianapolis predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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