Rams vs Bills Prediction and Preview - NFL Week 5, 2026

The Los Angeles Rams will take on the Buffalo Bills in NFL Week 5 action at SoFi Stadium on Tuesday, October 13, starting at 11:15am AEDT.

This article features Stats Insider's prediction and tips for the Rams vs Bills game, along with the latest betting odds and touchdown scorer tips.

Who Will Win?

Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Bills vs Rams 10,000 times.

Our proven predictive analytics model currently gives the Rams a 61% chance of winning against the Bills at SoFi Stadium.

Rams vs Bills: Odds

The current Bet365 betting odds in Australia for this NFL game at SoFi Stadium are listed below:

• Head to Head: Rams $1.64, Bills $2.30
• Line: Rams -2.5 ($1.91), Bills +2.5 ($1.91)
• Total (Over/Under 54.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Rams at $1.64 and the Bills at $2.30.

The Rams are listed as 2.5-point favourites against the Bills, with odds of $1.91 available at Bet365.

For the underdog Bills (+2.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 54.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Rams (-2.5) are predicted to cover the line 55% of the time, while the 54.5-point over/under is expected to stay under 60% of the time.

Rams vs Bills: Betting Tips

• Head to Head: LA Rams at $1.64 with Bet365
• Line: Rams -2.5 at $1.91 with Bet365
• Total Points: Under 54.5 at $1.91 with Bet365

If you see a 🔥, you know it's one of Stats Insider's best bets of the day across any sport.

Our Rams vs Bills betting tips are based on world-class simulations and wagering intelligence to bring you the best possible advice every day of the year.

Rams vs Bills: Prediction

Stats Insider's predicted final score for Rams vs Bills at SoFi Stadium in Week 5 is the Rams winning 27-24.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the LA Rams vs Buffalo game in Week 5, including data-driven predictions and live win probabilitiestips.

18+. Odds correct at time of publishing and subject to change.

Rams vs Bills: TD Scorer Tips

Who will score the first touchdown in Rams vs Bills? The latest data is in.

According to Stats Insider, Los Angeles' Kyren Williams is the most likely player to score the first TD in Rams vs Bills.

Williams has a 14.1% chance of scoring the first TD at SoFi Stadium, while the Rams RB has a 61.3% chance of reaching the end zone at any point in the game.

Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.

First Touchdown Scorer Tips

Rams First TD Tips

• Kyren Williams: 14.1% probability
• Puka Nacua: 10.1% probability
• Davante Adams: 8.1% probability
• Blake Corum: 5.6% probability
• Tyler Higbee: 5.2% probability

Bills First TD Tips

• Josh Allen: 12.4% probability
• James Cook: 10.1% probability
• DJ Moore: 5.5% probability
• Dalton Kincaid: 3.6% probability
• Keon Coleman: 2.9% probability

Anytime Touchdown Scorer Tips

Rams Anytime TD Tips

• Kyren Williams: 61.3% probability
• Puka Nacua: 49.3% probability
• Davante Adams: 42.0% probability
• Blake Corum: 31.5% probability
• Tyler Higbee: 29.7% probability

Bills Anytime TD Tips

• Josh Allen: 56.6% probability
• James Cook: 49.2% probability
• DJ Moore: 31.1% probability
• Dalton Kincaid: 21.3% probability
• Keon Coleman: 17.8% probability

Rams-Bills Projected Player Stats

Of the starting quarterbacks, the Rams' Matthew Stafford is projected for 278 passing yards. The Bills' Josh Allen is expected to throw for 249 yards.

Rams Starting QB

• Matthew Stafford: 278 projected passing yards

Bills Starting QB

• Josh Allen: 249 projected passing yards

Rams Rushing Yards

• Kyren Williams: 75 projected yards
• Blake Corum: 43 projected yards
• Matthew Stafford: 3 projected yards

Bills Rushing Yards

• James Cook: 80 projected yards
• Josh Allen: 40 projected yards
• Ty Johnson: 13 projected yards

Rams Receiving Yards

• Puka Nacua: 96 projected yards
• Davante Adams: 67 projected yards
• Tyler Higbee: 36 projected yards
• Kyren Williams: 25 projected yards
• Colby Parkinson: 17 projected yards

Bills Receiving Yards

• Dalton Kincaid: 49 projected yards
• Khalil Shakir: 45 projected yards
• DJ Moore: 41 projected yards
• Keon Coleman: 39 projected yards
• Joshua Palmer: 26 projected yards

Remember, our model updates regularly, so keep checking this article for the latest betting tips before the LA Rams vs Buffalo game.

As always, see our Best Bets to get the best tips on every NFL game, plus predictions for a wide range of other sports.

Rams vs Bills: Week 5 Essential Details

The NFL Week 5 game between the Rams and Bills at SoFi Stadium is scheduled to begin at 11:15am AEDT on Tuesday, October 13.

• Teams: Los Angeles Rams vs Buffalo Bills
• Date: Tuesday 13 October 2026
• Time: 11:15am AEDT
• Venue: SoFi Stadium

All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.

Conclusion

Our LA Rams vs Buffalo predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.

If you choose to use our NFL predictions for betting purposes, it's important that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

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