Rams vs 49ers Prediction and Preview - NFL Week 5, 2025
Last updated: Oct 3, 2025, 12:12AM | Published: Sep 30, 2025, 6:56AM
The Los Angeles Rams will take on the San Francisco 49ers in NFL Week 5 action at SoFi Stadium on Friday, beginning at 10:15am AEST.
This article features Stats Insider's prediction and tips for the Rams vs 49ers game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Friday's LA Rams vs San Francisco NFL game 10,000 times.
Our proven predictive analytics model gives the Rams a 76% chance of winning against the 49ers in Week 5 of the NFL season.
Rams vs 49ers: Odds
The current Bet365 betting odds in Australia for Friday's NFL game at SoFi Stadium are listed below:
- Head to Head: Rams $1.24, 49ers $4.25
- Line: Rams -8 ($1.91), 49ers +8 ($1.91)
- Total (Over/Under 44 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Rams at $1.24 and the 49ers at $4.25.
The Rams are 8-point favourites against the 49ers, with odds of $1.91 available at Bet365.
For the underdog 49ers (+8) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 44 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the 49ers (+8) are predicted to cover the line 52% of the time, while the 44-point over/under is expected to stay under 52% of the time.
Rams vs 49ers: Best Bets
- Head to Head: San Francisco at $4.25 with Bet365
- Line: 49ers +8 at $1.91 with Bet365
- Total Points: Under 44 at $1.91 with Bet365
Stats Insider's Rams vs 49ers best bets are based on complex simulations and gambling experience to help you place better bets with your chosen online bookie.
While the Rams have a higher chance of winning the game, betting on the 49ers to win is our preferred option due to the edge found when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges seen here at Stats Insider is pivotal to being profitable in the long run.
Rams vs 49ers: Prediction
Stats Insider's predicted final score for Rams vs 49ers at SoFi Stadium in Week 5 is the Rams winning 25-18.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the LA Rams vs San Francisco game in Week 5, including data-driven predictions and computer tips.
18+. Odds correct at time of publishing and subject to change.Rams vs 49ers: TD Scorer Tips
Who will score an anytime touchdown in Rams vs 49ers? The data is in.
According to Stats Insider, Los Angeles' Kyren Williams is the most likely player to score the first TD in Rams vs 49ers.
Williams has a 15.4% chance of scoring the first TD at SoFi Stadium, while the Rams RB has a 54.1% chance of reaching the end zone at any point in the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Rams First TD Tips
- Kyren Williams: 15.4% probability
- Davante Adams: 10.7% probability
- Puka Nacua: 10.6% probability
- Blake Corum: 4.8% probability
- Jordan Whittington: 2.7% probability
49ers First TD Tips
- Christian McCaffrey: 14.6% probability
- Kendrick Bourne: 4.4% probability
- Demarcus Robinson: 4.2% probability
- Jake Tonges: 3.5% probability
- Brian Robinson: 3.5% probability
Anytime Touchdown Scorer Tips
Rams Anytime TD Tips
- Kyren Williams: 54.1% probability
- Davante Adams: 41.7% probability
- Puka Nacua: 41.5% probability
- Blake Corum: 21.5% probability
- Jordan Whittington: 12.7% probability
49ers Anytime TD Tips
- Christian McCaffrey: 52.9% probability
- Kendrick Bourne: 20.3% probability
- Demarcus Robinson: 19.4% probability
- Jake Tonges: 16.6% probability
- Brian Robinson: 16.5% probability
Rams-49ers Projected Player Stats
Of the starting quarterbacks, the Rams' Matthew Stafford is projected for 242 passing yards, while the 49ers' Mac Jones is expected to throw for 222 yards.
Rams Starting QB
- Matthew Stafford: 242 projected passing yards
49ers Starting QB
- Mac Jones: 222 projected passing yards
Rams Rushing Yards
- Kyren Williams: 72 projected yards
- Blake Corum: 33 projected yards
- Jordan Whittington: 6 projected yards
49ers Rushing Yards
- Christian McCaffrey: 66 projected yards
- Brian Robinson: 22 projected yards
- Mac Jones: 9 projected yards
Rams Receiving Yards
- Puka Nacua: 99 projected yards
- Davante Adams: 62 projected yards
- Jordan Whittington: 20 projected yards
- Tutu Atwell: 16 projected yards
- Colby Parkinson: 15 projected yards
49ers Receiving Yards
- Christian McCaffrey: 53 projected yards
- Kendrick Bourne: 47 projected yards
- Demarcus Robinson: 39 projected yards
- Jake Tonges: 32 projected yards
- Skyy Moore: 14 projected yards
Remember, our model updates frequently, so keep checking this page for the latest betting analysis before the LA Rams vs San Francisco match-up.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, as well as predictions for a wide range of other sports.
Rams vs 49ers: Week 5 Essential Details
The NFL Week 5 game between the Rams and 49ers at SoFi Stadium is scheduled to begin at 10:15am AEST on Friday.
- Teams: Los Angeles Rams vs San Francisco 49ers
- Date: Friday 3 October 2025
- Time: 10:15am AEST
- Venue: SoFi Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our LA Rams vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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