Rams vs 49ers Prediction and Preview - NFL Week 5, 2025
Last updated: Sep 30, 2025, 6:52AM | Published: Sep 30, 2025, 6:46AM
The Los Angeles Rams will face the San Francisco 49ers in NFL Week 5 action at SoFi Stadium on Friday, beginning at 10:15am AEST.
This article features Stats Insider's prediction and tips for the Rams vs 49ers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the result of Friday's LA Rams vs San Francisco NFL game 10,000 times.
Our independent predictive analytics model gives the Rams a 69% chance of defeating the 49ers at SoFi Stadium.
Rams vs 49ers: Odds
The latest Bet365 betting odds in Australia for Friday's NFL game at SoFi Stadium are listed below:
- Head to Head: Rams $1.38, 49ers $3.10
- Line: Rams -5.5 ($1.91), 49ers +5.5 ($1.91)
- Total (Over/Under 47 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Rams at $1.38 and the 49ers at $3.10.
The Rams are 5.5-point favourites against the 49ers, with odds of $1.91 available at Bet365.
For the underdog 49ers (+5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Rams and the 49ers have a 50% chance of covering the line.
The 47-point over/under is expected to stay under 52% of the time.
Rams vs 49ers: Betting Tips
- Head to Head: San Francisco at $3.10 with Bet365
- Line: 49ers +5.5 at $1.91 with Bet365
- Total Points: Under 47 at $1.91 with Bet365
Stats Insider's Rams vs 49ers best bets are based on world-class simulations and betting intelligence to help you place better bets with your chosen online bookie.
While the Rams have a higher chance of winning the game, betting on the 49ers to win is our recommended option because of the edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges seen here at Stats Insider is crucial to achieving long-term success as a punter.
Rams vs 49ers: Prediction
Stats Insider's predicted final score for Rams vs 49ers at SoFi Stadium in Week 5 is the Rams winning 25-20.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the LA Rams vs San Francisco game in Week 5, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.Rams vs 49ers: TD Scorer Tips
Who will score the first touchdown in Rams vs 49ers? The latest data is in.
According to Stats Insider, San Francisco's Christian McCaffrey is the most likely player to score the first touchdown in Rams vs 49ers.
McCaffrey has a 15.4% chance of scoring the first TD at SoFi Stadium, while the 49ers RB has a 62.5% chance of reaching the end zone at any point in the game.
Scroll down for the complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Rams First TD Tips
- Kyren Williams: 14.8% probability
- Davante Adams: 10.3% probability
- Puka Nacua: 8.2% probability
- Blake Corum: 4.7% probability
- Tyler Higbee: 3.1% probability
49ers First TD Tips
- Christian McCaffrey: 15.4% probability
- Ricky Pearsall: 5.3% probability
- Jauan Jennings: 5.2% probability
- Brian Robinson: 3.7% probability
- Brock Purdy: 3.4% probability
Anytime Touchdown Scorer Tips
Rams Anytime TD Tips
- Kyren Williams: 53.6% probability
- Davante Adams: 41.3% probability
- Puka Nacua: 34.8% probability
- Blake Corum: 21.8% probability
- Tyler Higbee: 14.9% probability
49ers Anytime TD Tips
- Christian McCaffrey: 62.5% probability
- Ricky Pearsall: 28.6% probability
- Jauan Jennings: 28.4% probability
- Brian Robinson: 21.1% probability
- Brock Purdy: 19.7% probability
Rams-49ers Projected Player Stats
Of the starting quarterbacks, the Rams' Matthew Stafford is projected for 244 passing yards. The 49ers' Brock Purdy is expected to throw for 231 yards.
Rams Starting QB
- Matthew Stafford: 244 projected passing yards
49ers Starting QB
- Brock Purdy: 231 projected passing yards
Rams Rushing Yards
- Kyren Williams: 73 projected yards
- Blake Corum: 31 projected yards
- Puka Nacua: 4 projected yards
49ers Rushing Yards
- Christian McCaffrey: 71 projected yards
- Brock Purdy: 20 projected yards
- Brian Robinson: 18 projected yards
Rams Receiving Yards
- Puka Nacua: 101 projected yards
- Davante Adams: 58 projected yards
- Tyler Higbee: 18 projected yards
- Tutu Atwell: 17 projected yards
- Jordan Whittington: 15 projected yards
49ers Receiving Yards
- Jauan Jennings: 50 projected yards
- Ricky Pearsall: 50 projected yards
- Christian McCaffrey: 40 projected yards
- Jake Tonges: 18 projected yards
- Demarcus Robinson: 15 projected yards
Our model updates frequently, so refresh this article for the latest betting tips before the LA Rams vs San Francisco game.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, as well as predictions for a wide range of other sports.
Rams vs 49ers: Week 5 Essential Details
The NFL Week 5 match-up between the Rams and 49ers at SoFi Stadium is scheduled to start at 10:15am AEST on Friday.
- Teams: Los Angeles Rams vs San Francisco 49ers
- Date: Friday 3 October 2025
- Time: 10:15am AEST
- Venue: SoFi Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our LA Rams vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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