Rams vs 49ers Prediction and Preview - NFL Week 5, 2025

The Los Angeles Rams will take on the San Francisco 49ers in NFL Week 5 action at SoFi Stadium on Friday, commencing at 10:15am AEST.

This article features Stats Insider's prediction and tips for the Rams vs 49ers game, plus the latest betting odds in Australia.

Who Will Win?

Utilising trusted computer power and data, Stats Insider has simulated the outcome of Friday's LA Rams vs San Francisco NFL game 10,000 times.

Our leading predictive analytics model gives the Rams a 54% chance of beating the 49ers in Week 5 of the NFL season.

Rams vs 49ers: Odds

The latest Bet365 betting odds in Australia for Friday's NFL game at SoFi Stadium are shown below:

• Head to Head: Rams $1.62, 49ers $2.35
• Line: Rams -3 ($1.91), 49ers +3 ($1.91)
• Total (Over/Under 46.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Rams at $1.62 and the 49ers at $2.35.

The Rams are 3-point favourites against the 49ers, with odds of $1.91 available at Bet365.

For the underdog 49ers (+3) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 46.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the 49ers (+3) are predicted to cover the line 61% of the time, while the 46.5-point over/under is expected to is considered an equal 50-50 chance of hitting.

Rams vs 49ers: Betting Tips

• Head to Head: San Francisco at $2.35 with Bet365
• Line: 49ers +3 at $1.91 with Bet365
• Total Points: Under 46.5 at $1.91 with Bet365

If you see a 🔥, that means you've found one of Stats Insider's best bets of the day across all sports.

Our Rams vs 49ers best bets are based on market-leading simulations and wagering expertise to give you the best possible advice around the clock.

While the Rams have a higher chance of winning the game, betting on the 49ers to win is our recommended option due to the 3.6% edge found when comparing our data-led probabilities to the odds currently on offer.

Taking advantage of the edges published here at Stats Insider is pivotal to being a profitable punter in the long run.

Rams vs 49ers: Prediction

Stats Insider's predicted final score for Rams vs 49ers at SoFi Stadium in Week 5 is the Rams winning 23-22.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the LA Rams vs San Francisco game in Week 5, including data-driven predictions and top betting tips.

Remember, our model updates regularly, so bookmark this article for the latest betting tips before the LA Rams vs San Francisco game.

As always, see Stats Insider's Best Bets for betting tips on every NFL game, plus predictions for a wide range of other sports.

Rams vs 49ers: Week 5 Essential Details

The NFL Week 5 game between the Rams and 49ers at SoFi Stadium is scheduled to begin at 10:15am AEST on Friday.

• Teams: Los Angeles Rams vs San Francisco 49ers
• Date: Friday 3 October 2025
• Time: 10:15am AEST
• Venue: SoFi Stadium

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our LA Rams vs San Francisco predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.

If you decide to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on NFL

Stats Insider is your home for betting on the NFL in Australia, with the latest NFL betting news, predictions for every NFL game, and Super Bowl odds for the NFL.