Pirates vs Cubs Prediction and MLB Tips - 18 September 2025
Last updated: Sep 17, 2025, 4:35PM | Published: Sep 16, 2025, 7:29PM
The Pittsburgh Pirates will sqaure off with the Chicago Cubs in MLB action at PNC Park on Thursday, starting at 2:35am AEST.
Johan Oviedo (2-0, 2.80 ERA) will start for the Pirates, up against Matthew Boyd (13-8, 3.05 ERA) for the Cubs.
This article features Stats Insider's prediction and tips for the Pirates vs Cubs game, as well as the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the result of Thursday's Pittsburgh vs Cubs MLB match-up 10,000 times.
Our independent predictive analytics model currently gives the Cubs a 55% chance of defeating the Pirates at PNC Park.
Pirates vs Cubs: Odds
The current betting odds in Australia for Thursday's MLB game at PNC Park are shown here:
- Head to Head: Pirates $2.20, Cubs $1.71
- Line: Pirates +1.5 ($1.72), Cubs -1.5 ($2.20)
- Total (Over/Under 7.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $2.20 and the Cubs at $1.71.
The Pirates are 1.5-run underdogs against the Cubs, with odds of $1.72 available at TAB.
For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.20.
The over/under for total runs scored is set at 7.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Pirates (+1.5) are predicted to cover the line 58% of the time, while the 7.5-run over/under is expected to go over 51% of the time.
Pirates vs Cubs: Betting Tips
- Head to Head: Pittsburgh at $2.20 with TAB
- Line: Pirates +1.5 at $1.72 with TAB
- Total Runs: Over 7.5 at $1.91 with TAB
Our Pirates vs Cubs betting tips are based on complex modelling and gambling intelligence to help you place better bets with your chosen online bookie.
While the Cubs have a higher chance of winning the game, betting on the Pirates to win is our recommended option because of the 1.4% edge found when comparing our data-led probabilities to the odds currently on offer.
Taking advantage of the edges published on Stats Insider is pivotal to achieving long-term profitability.
Pirates vs Cubs: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs Cubs game on Thursday, including data-driven predictions and expert tips.
Remember, our model updates frequently, so refresh this page for the latest betting analysis before the Pittsburgh vs Cubs match-up.
As always, see Stats Insider's Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.
Pirates vs Cubs: Essential Details
The game between the Pirates and Cubs at PNC Park is scheduled to start at 2:35am AEST on Thursday.
- Teams: Pittsburgh Pirates vs Chicago Cubs
- Date: Thursday 18 September 2025
- Time: 2:35am AEST
- Venue: PNC Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Pittsburgh vs Cubs predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our MLB predictions for betting purposes, it's important to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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