Pirates vs Cubs Prediction and MLB Tips - 17 September 2025
Last updated: Sep 16, 2025, 10:45PM | Published: Sep 15, 2025, 8:31PM
The Pittsburgh Pirates will sqaure off with the Chicago Cubs in MLB action at PNC Park on Wednesday, starting at 8:40am AEST.
Paul Skenes (10-9, 1.92 ERA) will start for the Pirates, up against Cade Horton (10-4, 2.70 ERA) for the Cubs.
This article features Stats Insider's prediction and tips for the Pirates vs Cubs game, as well as the latest betting odds in Australia.
Who Will Win?
Utilising trusted machine learning and data, Stats Insider has simulated the result of Wednesday's Pittsburgh vs Cubs MLB match-up 10,000 times.
Our independent predictive analytics model gives the Pirates a 54% chance of defeating the Cubs at PNC Park.
Pirates vs Cubs: Odds
The latest betting odds in Australia for Wednesday's MLB game at PNC Park are listed below:
- Head to Head: Pirates $1.77, Cubs $2.10
- Line: Pirates -1.5 ($2.74), Cubs +1.5 ($1.47)
- Total (Over/Under 6.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $1.77 and the Cubs at $2.10.
The Pirates are 1.5-run favourites against the Cubs, with odds of $2.74 available at TAB.
For the underdog Cubs (+1.5) to cover the line, TAB offers odds of $1.47.
The over/under for total runs scored is set at 6.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cubs (+1.5) are predicted to cover the line 65% of the time, while the 6.5-run over/under is expected to go over 54% of the time.
Pirates vs Cubs: Betting Tips
- Head to Head: Cubs at $2.10 with TAB
- Line: Cubs +1.5 at $1.47 with TAB
- Total Runs: Over 6.5 at $1.91 with TAB
Today's Pirates vs Cubs betting tips are based on detailed simulations and gambling intelligence to give you the best possible advice around the clock.
While the Pirates have a higher chance of winning the game, betting on the Cubs to win is our preferred option because of the edge identified when comparing our data-led probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is one of the keys to achieving long-term success as a bettor.
Pirates vs Cubs: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs Cubs game on Wednesday, including data-driven predictions and free betting tips.
Our model updates frequently, so keep checking this article for the latest betting analysis before the Pittsburgh vs Cubs match-up.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, plus predictions for a wide range of other sports.
Pirates vs Cubs: Essential Details
The match-up between the Pirates and Cubs at PNC Park is scheduled to begin at 8:40am AEST on Wednesday.
- Teams: Pittsburgh Pirates vs Chicago Cubs
- Date: Wednesday 17 September 2025
- Time: 8:40am AEST
- Venue: PNC Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Pittsburgh vs Cubs predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our MLB predictions for betting purposes, it's important that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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