Pirates vs Cubs Prediction and MLB Tips - 17 September 2025
Last updated: Sep 16, 2025, 2:11PM | Published: Sep 15, 2025, 8:31PM
The Pittsburgh Pirates will take on the Chicago Cubs in MLB action at PNC Park on Wednesday, beginning at 8:40am AEST.
Paul Skenes (10-9, 1.92 ERA) will get the ball for the Pirates, pitting him against Cade Horton (10-4, 2.70 ERA) for the Cubs.
This article features Stats Insider's free betting tips for the Pirates vs Cubs game, plus the latest betting odds in Australia.
Who Will Win?
Using trusted machine learning and data, Stats Insider has simulated the outcome of Wednesday's Pittsburgh vs Cubs MLB match-up 10,000 times.
Our leading predictive analytics model currently gives the Pirates a 55% chance of defeating the Cubs at PNC Park.
Pirates vs Cubs: Odds
The latest betting odds in Australia for Wednesday's MLB game at PNC Park are shown below:
- Head to Head: Pirates $1.77, Cubs $2.10
- Line: Pirates -1.5 ($2.70), Cubs +1.5 ($1.49)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $1.77 and the Cubs at $2.10.
The Pirates are 1.5-run favourites against the Cubs, with odds of $2.70 available at TAB.
For the underdog Cubs (+1.5) to cover the line, TAB offers odds of $1.49.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cubs (+1.5) are predicted to cover the line 64% of the time, while the 7-run over/under is expected to stay under 51% of the time.
Pirates vs Cubs: Betting Tips
- Head to Head: Pittsburgh at $1.77 with TAB
- Line: Pirates -1.5 at $2.70 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Our Pirates vs Cubs best bets are based on world-class modelling and wagering experience to provide you with the best possible advice every time.
Although the Cubs are more likely to cover the line, our best bet of Pirates -1.5 is based on the chance of that happening, as suggested by our predictive analytics model, and the best odds available.
Furthermore, despite the Under being more likely to hit in this game, Over 7 is our best bet because of the better odds ($1.91) that are available from TAB.
Pirates vs Cubs: Prediction
Stats Insider provides full coverage of the Pittsburgh vs Cubs game on Wednesday, including data-driven predictions and the best betting tips.
Our model updates regularly, so refresh this article for the latest betting tips before the Pittsburgh vs Cubs game.
As always, see our Best Bets to get the best tips on every MLB game, plus predictions for a wide range of other sports.
Pirates vs Cubs: Essential Details
The game between the Pirates and Cubs at PNC Park is scheduled to start at 8:40am AEST on Wednesday.
- Teams: Pittsburgh Pirates vs Chicago Cubs
- Date: Wednesday 17 September 2025
- Time: 8:40am AEST
- Venue: PNC Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Pittsburgh vs Cubs predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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