Pirates vs Cubs Prediction and MLB Tips - 16 September 2025
Last updated: Sep 15, 2025, 10:42PM | Published: Sep 14, 2025, 7:29PM
The Pittsburgh Pirates will take on the Chicago Cubs in MLB action at PNC Park on Tuesday, starting at 8:40am AEST.
The Pirates will send Braxton Ashcraft (4-2, 2.47 ERA) to the mound, pitting him against Jameson Taillon (9-6, 4.15 ERA) for the Cubs.
This article features Stats Insider's prediction and tips for the Pirates vs Cubs game, along with the latest betting odds in Australia.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the outcome of Tuesday's Pittsburgh vs Cubs MLB game 10,000 times.
Our independent predictive analytics model gives the Cubs a 52% chance of winning against the Pirates at PNC Park.
Pirates vs Cubs: Odds
The current betting odds in Australia for Tuesday's MLB game at PNC Park are shown here:
- Head to Head: Pirates $2.00, Cubs $1.83
- Line: Pirates +1.5 ($1.61), Cubs -1.5 ($2.40)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $2.00 and the Cubs at $1.83.
The Pirates are 1.5-run underdogs against the Cubs, with odds of $1.61 available at TAB.
For the favourite Cubs (-1.5) to cover the line, TAB offers odds of $2.40.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Pirates (+1.5) are predicted to cover the line 61% of the time, while the 8-run over/under is expected to is considered an equal 50-50 chance of hitting.
Pirates vs Cubs: Betting Tips
- Head to Head: Pittsburgh at $2.00 with TAB
- Line: Pirates +1.5 at $1.61 with TAB
- Total Runs: Over 8 at $1.91 with TAB
Our Pirates vs Cubs predictions are based on market-leading modelling and gambling expertise to bring you the best possible advice 24/7.
While the Cubs have a higher chance of winning the game, betting on the Pirates to win is our recommended option due to the edge identified when comparing our data-led probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is pivotal to achieving long-term success as a sports bettor.
Pirates vs Cubs: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs Cubs game on Tuesday, including data-driven predictions and live win probabilitiestips.
Remember, our model updates frequently, so refresh this article for the latest betting predictions before the Pittsburgh vs Cubs game.
As always, see our Best Bets to get the best tips on every MLB game, as well as predictions for a wide range of other sports.
Pirates vs Cubs: Essential Details
The game between the Pirates and Cubs at PNC Park is scheduled to start at 8:40am AEST on Tuesday.
- Teams: Pittsburgh Pirates vs Chicago Cubs
- Date: Tuesday 16 September 2025
- Time: 8:40am AEST
- Venue: PNC Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Pittsburgh vs Cubs predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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