Pirates vs Cardinals Prediction and MLB Tips - 25 September 2026
Last updated: Sep 24, 2026, 1:45AM | Published: Sep 23, 2026, 7:28PM
The Pittsburgh Pirates will sqaure off with the St. Louis Cardinals in MLB action at PNC Park on Friday, starting at 2:35am AEST.
The Pirates will have Paul Skenes (10-11, 3.91 ERA) start, pitting him against Kyle Leahy (10-5, 3.65 ERA) for the Cardinals.
This article features Stats Insider's best betting tips for the Pirates vs Cardinals game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the outcome of Friday's Pittsburgh vs St. Louis MLB game 10,000 times.
Our leading predictive analytics model currently gives the Pirates a 60% chance of beating the Cardinals at PNC Park.
Pirates vs Cardinals: Odds
The current betting odds in Australia for Friday's MLB game at PNC Park are shown below:
- Head to Head: Pirates $1.61, Cardinals $2.40
- Line: Pirates -1.5 ($2.45), Cardinals +1.5 ($1.59)
- Total (Over/Under 6.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $1.61 and the Cardinals at $2.40.
The Pirates are 1.5-run favourites against the Cardinals, with odds of $2.45 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.59.
The over/under for total runs scored is set at 6.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Cardinals (+1.5) are predicted to cover the line 60% of the time, while the 6.5-run over/under is expected to go over 56% of the time.
Pirates vs Cardinals: Best Bets
- Head to Head: Pittsburgh at $1.61 with TAB
- Line: Pirates -1.5 at $2.45 with TAB
- Total Runs: Over 6.5 at $1.91 with TAB
Our Pirates vs Cardinals predictions are based on complex modelling and betting experience to give you the best possible advice around the clock.
Although the Cardinals are more likely to cover the line, our best bet of Pirates -1.5 is based on the chance of that happening, as suggested by our predictive analytics model, and the best odds available.
Pirates vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs St. Louis game on Friday, including data-driven predictions and the best betting tips.
Our model updates frequently, so refresh this article for the latest betting analysis before the Pittsburgh vs St. Louis match-up.
As always, see our Best Bets to get the best tips for every MLB game, plus predictions for a wide range of other sports.
Pirates vs Cardinals: Essential Details
The match-up between the Pirates and Cardinals at PNC Park is scheduled to begin at 2:35am AEST on Friday.
- Teams: Pittsburgh Pirates vs St. Louis Cardinals
- Date: Friday 25 September 2026
- Time: 2:35am AEST
- Venue: PNC Park
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Pittsburgh vs St. Louis predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our MLB predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures odds for the MLB.
