Pirates vs Cardinals Prediction and MLB Tips - 25 September 2026
Last updated: Sep 24, 2026, 4:35PM | Published: Sep 23, 2026, 7:28PM
The Pittsburgh Pirates will sqaure off with the St. Louis Cardinals in MLB action at PNC Park on Friday, beginning at 2:35am AEST.
Paul Skenes (10-11, 3.91 ERA) will start on the mound for the Pirates, while the Cardinals are going with Kyle Leahy (10-5, 3.65 ERA).
This article features Stats Insider's best betting tips for the Pirates vs Cardinals game, plus the latest betting odds in Australia.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Friday's Pittsburgh vs St. Louis MLB game 10,000 times.
Our proven predictive analytics model gives the Pirates a 60% chance of defeating the Cardinals at PNC Park.
Pirates vs Cardinals: Odds
The latest betting odds in Australia for Friday's MLB game at PNC Park are listed below:
- Head to Head: Pirates $1.60, Cardinals $2.40
- Line: Pirates -1.5 ($2.35), Cardinals +1.5 ($1.61)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $1.60 and the Cardinals at $2.40.
The Pirates are listed as 1.5-run favourites against the Cardinals, with odds of $2.35 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.61.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 59% of the time, while the 7-run over/under is expected to go over 51% of the time.
Pirates vs Cardinals: Betting Tips
- Head to Head: Pittsburgh at $1.60 with TAB
- Line: Pirates -1.5 at $2.35 with TAB
- Total Runs: Over 7 at $1.91 with TAB
These Pirates vs Cardinals betting tips are based on world-class modelling and gambling experience to give you the best possible advice around the clock.
Even though the Cardinals are more likely to cover the line, our best bet of Pirates -1.5 is based on the chance of that happening, as projected by our predictive analytics model, and the top odds available.
Pirates vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs St. Louis game on Friday, including data-driven predictions and live win probabilitiestips.
Our model updates frequently, so bookmark this page for the latest betting tips before the Pittsburgh vs St. Louis match-up.
As always, see Stats Insider's Best Bets for the best tips for every MLB game, as well as predictions for a wide range of other sports.
Pirates vs Cardinals: Essential Details
The match-up between the Pirates and Cardinals at PNC Park is scheduled to begin at 2:35am AEST on Friday.
- Teams: Pittsburgh Pirates vs St. Louis Cardinals
- Date: Friday 25 September 2026
- Time: 2:35am AEST
- Venue: PNC Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our Pittsburgh vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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