Pirates vs Cardinals Prediction and MLB Tips - 23 September 2026
Last updated: Sep 22, 2026, 12:27PM | Published: Sep 21, 2026, 5:27PM
The Pittsburgh Pirates will face the St. Louis Cardinals in MLB action at PNC Park on Wednesday, beginning at 8:40am AEST.
Jared Jones (4-6, 4.17 ERA) will start on the mound for the Pirates, while the Cardinals are going with Andre Pallante (12-7, 3.70 ERA).
This article features Stats Insider's best betting tips for the Pirates vs Cardinals game, plus the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Wednesday's Pittsburgh vs St. Louis MLB match-up 10,000 times.
Our independent predictive analytics model gives the Pirates a 58% chance of defeating the Cardinals at PNC Park.
Pirates vs Cardinals: Odds
The latest betting odds in Australia for Wednesday's MLB game at PNC Park are shown below:
- Head to Head: Pirates $1.67, Cardinals $2.25
- Line: Pirates -1.5 ($2.50), Cardinals +1.5 ($1.56)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $1.67 and the Cardinals at $2.25.
The Pirates are 1.5-run favourites against the Cardinals, with odds of $2.50 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.56.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 60% of the time, while the 7-run over/under is expected to go over 56% of the time.
Pirates vs Cardinals: Betting Tips
- Head to Head: Pittsburgh at $1.67 with TAB
- Line: Pirates -1.5 at $2.50 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Our Pirates vs Cardinals betting tips are based on market-leading modelling and betting expertise to provide you with the best possible advice 24/7/365.
Although the Cardinals are more likely to cover the line, our best bet of Pirates -1.5 is based on the chance of that happening, as suggested by our predictive analytics model, and the best odds available.
Pirates vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs St. Louis game on Wednesday, including data-driven predictions and free betting tips.
Our model updates regularly, so bookmark this page for the latest betting tips before the Pittsburgh vs St. Louis match-up.
As always, see Stats Insider's Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Pirates vs Cardinals: Essential Details
The game between the Pirates and Cardinals at PNC Park is scheduled to begin at 8:40am AEST on Wednesday.
- Teams: Pittsburgh Pirates vs St. Louis Cardinals
- Date: Wednesday 23 September 2026
- Time: 8:40am AEST
- Venue: PNC Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Pittsburgh vs St. Louis predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our MLB tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our predictions for betting purposes, it's crucial to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your go-to source for betting on the MLB in Australia, with the latest MLB betting news, tips for every MLB game, and futures odds for the MLB.
