Pirates vs Cardinals Prediction and MLB Tips - 23 September 2026
Last updated: Sep 22, 2026, 10:36PM | Published: Sep 21, 2026, 5:27PM
The Pittsburgh Pirates will sqaure off with the St. Louis Cardinals in MLB action at PNC Park on Wednesday, commencing at 8:40am AEST.
The Pirates will have Jared Jones (4-6, 4.17 ERA) start, while the Cardinals will counter with Andre Pallante (12-7, 3.70 ERA).
This article features Stats Insider's prediction and tips for the Pirates vs Cardinals game, as well as the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Wednesday's Pittsburgh vs St. Louis MLB game 10,000 times.
Our proven predictive analytics model gives the Pirates a 60% chance of winning against the Cardinals at PNC Park.
Pirates vs Cardinals: Odds
The current betting odds in Australia for Wednesday's MLB game at PNC Park are shown here:
- Head to Head: Pirates $1.61, Cardinals $2.40
- Line: Pirates -1.5 ($2.35), Cardinals +1.5 ($1.62)
- Total (Over/Under 7 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Pirates at $1.61 and the Cardinals at $2.40.
The Pirates are 1.5-run favourites against the Cardinals, with odds of $2.35 available at TAB.
For the underdog Cardinals (+1.5) to cover the line, TAB offers odds of $1.62.
The over/under for total runs scored is set at 7 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the Cardinals (+1.5) are predicted to cover the line 59% of the time, while the 7-run over/under is expected to go over 54% of the time.
Pirates vs Cardinals: Betting Tips
- Head to Head: St. Louis at $2.40 with TAB
- Line: Pirates -1.5 at $2.35 with TAB
- Total Runs: Over 7 at $1.91 with TAB
Stats Insider's Pirates vs Cardinals betting tips are based on detailed simulations and wagering expertise to help you place better bets with your chosen online bookie.
And while the Pirates have a higher chance of winning the game, betting on the Cardinals to win is our recommended option because of the edge found when comparing our data-led probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is one of the keys to being profitable in the long run.
Even though the Cardinals are more likely to cover the line, our best bet of Pirates -1.5 is based on the chance of that happening, as projected by our predictive analytics model, and the best odds available.
Pirates vs Cardinals: Prediction
Stats Insider provides full betting coverage of the Pittsburgh vs St. Louis game on Wednesday, including data-driven predictions and top betting tips.
Remember, our model updates regularly, so keep checking this article for the latest betting tips before the Pittsburgh vs St. Louis match-up.
As always, see our Best Bets for betting tips for every MLB game, as well as predictions for a wide range of other sports.
Pirates vs Cardinals: Essential Details
The game between the Pirates and Cardinals at PNC Park is scheduled to start at 8:40am AEST on Wednesday.
- Teams: Pittsburgh Pirates vs St. Louis Cardinals
- Date: Wednesday 23 September 2026
- Time: 8:40am AEST
- Venue: PNC Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Pittsburgh vs St. Louis predictions are the result of 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, giving you the confidence to make informed decisions.
If you decide to use our predictions for betting purposes, it's vital that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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