Patriots vs Panthers Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 26, 2025, 7:46PM | Published: Sep 21, 2025, 4:02AM
The New England Patriots will face the Carolina Panthers in NFL Week 4 action at Gillette Stadium on Monday, starting at 3:00am AEST.
This article features Stats Insider's prediction and tips for the Patriots vs Panthers game, as well as the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising trusted computer power and data, Stats Insider has simulated the result of Monday's New England vs Carolina NFL match-up 10,000 times.
Our independent predictive analytics model gives the Patriots a 69% chance of winning against the Panthers in Week 4 of the NFL season.
Patriots vs Panthers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Gillette Stadium are listed below:
- Head to Head: Patriots $1.40, Panthers $3.05
- Line: Patriots -5.5 ($1.91), Panthers +5.5 ($1.91)
- Total (Over/Under 43 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Patriots at $1.40 and the Panthers at $3.05.
The Patriots are 5.5-point favourites against the Panthers, with odds of $1.91 available at Bet365.
For the underdog Panthers (+5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 43 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Patriots and the Panthers have a 50% chance of covering the line.
The 43-point over/under is expected to go over 58% of the time.
Patriots vs Panthers: Best Bets
- Head to Head: Carolina at $3.05 with Bet365
- Line: Panthers +5.5 at $1.91 with Bet365
- Total Points: Over 43 at $1.91 with Bet365
When you see a 🔥, you know you've found one of Stats Insider's best bets for today across all sports.
These Patriots vs Panthers betting tips are based on market-leading modelling and wagering experience to bring you the best possible advice 24/7/365.
While the Patriots have a higher chance of winning the game, betting on the Panthers to win is our recommended option because of the edge identified when comparing our data-driven probabilities to the odds currently available.
Making use of the edges published on Stats Insider is crucial to being a profitable sports bettor in the long run.
Patriots vs Panthers: Prediction
Stats Insider's predicted final score for Patriots vs Panthers at Gillette Stadium in Week 4 is the Patriots winning 24-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the New England vs Carolina game in Week 4, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.Patriots vs Panthers: TD Scorer Tips
Who will score the first touchdown in Patriots vs Panthers? The latest data is in.
According to Stats Insider, Carolina's Chuba Hubbard is the most likely player to score the first touchdown in Patriots vs Panthers.
Hubbard has a 9.7% chance of scoring the first TD at Gillette Stadium, while the Panthers RB has a 43.1% chance of scoring an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Patriots First TD Tips
- Rhamondre Stevenson: 8.1% probability
- TreVeyon Henderson: 8.0% probability
- Hunter Henry: 6.6% probability
- Stefon Diggs: 5.9% probability
- Kayshon Boutte: 4.7% probability
Panthers First TD Tips
- Chuba Hubbard: 9.7% probability
- Tetairoa McMillan: 7.2% probability
- Rico Dowdle: 6.0% probability
- Hunter Renfrow: 4.0% probability
- Bryce Young: 2.9% probability
Anytime Touchdown Scorer Tips
Patriots Anytime TD Tips
- Rhamondre Stevenson: 33.5% probability
- TreVeyon Henderson: 33.2% probability
- Hunter Henry: 28.3% probability
- Stefon Diggs: 25.8% probability
- Kayshon Boutte: 21.0% probability
Panthers Anytime TD Tips
- Chuba Hubbard: 43.1% probability
- Tetairoa McMillan: 34.3% probability
- Rico Dowdle: 29.2% probability
- Hunter Renfrow: 20.8% probability
- Bryce Young: 15.3% probability
Patriots-Panthers Projected Player Stats
Of the starting quarterbacks, the Patriots' Drake Maye is projected for 219 passing yards. The Panthers' Bryce Young is expected to throw for 218 yards.
Patriots Starting QB
- Drake Maye: 219 projected passing yards
Panthers Starting QB
- Bryce Young: 218 projected passing yards
Patriots Rushing Yards
- TreVeyon Henderson: 39 projected yards
- Rhamondre Stevenson: 37 projected yards
- Drake Maye: 28 projected yards
Panthers Rushing Yards
- Chuba Hubbard: 55 projected yards
- Rico Dowdle: 21 projected yards
- Bryce Young: 18 projected yards
Patriots Receiving Yards
- Stefon Diggs: 43 projected yards
- Hunter Henry: 43 projected yards
- Kayshon Boutte: 34 projected yards
- TreVeyon Henderson: 20 projected yards
- Mack Hollins: 18 projected yards
Panthers Receiving Yards
- Tetairoa McMillan: 67 projected yards
- Hunter Renfrow: 31 projected yards
- Tommy Tremble: 25 projected yards
- Brycen Tremayne: 22 projected yards
- Chuba Hubbard: 20 projected yards
Our model updates regularly, so bookmark this article for the latest betting analysis before the New England vs Carolina game.
As always, see Stats Insider's Best Bets to get betting tips for every NFL game, as well as predictions for a wide range of other sports.
Patriots vs Panthers: Week 4 Essential Details
The NFL Week 4 match-up between the Patriots and Panthers at Gillette Stadium is scheduled to commence at 3:00am AEST on Monday.
- Teams: New England Patriots vs Carolina Panthers
- Date: Monday 29 September 2025
- Time: 3:00am AEST
- Venue: Gillette Stadium
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our New England vs Carolina predictions are based on 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
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