Patriots vs Panthers Prediction and Preview - NFL Week 4, 2025
Last updated: Sep 28, 2025, 5:03PM | Published: Sep 21, 2025, 4:02AM
The New England Patriots will face the Carolina Panthers in NFL Week 4 action at Gillette Stadium on Monday, beginning at 3:00am AEST.
This article features Stats Insider's prediction and tips for the Patriots vs Panthers game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Using trusted computer power and data, Stats Insider has simulated the outcome of Monday's New England vs Carolina NFL match-up 10,000 times.
Our leading predictive analytics model gives the Patriots a 70% chance of beating the Panthers at Gillette Stadium.
Patriots vs Panthers: Odds
The latest Bet365 betting odds in Australia for Monday's NFL game at Gillette Stadium are shown here:
- Head to Head: Patriots $1.41, Panthers $3.00
- Line: Patriots -5.5 ($1.91), Panthers +5.5 ($1.91)
- Total (Over/Under 42.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Patriots at $1.41 and the Panthers at $3.00.
The Patriots are 5.5-point favourites against the Panthers, with odds of $1.91 available at Bet365.
For the underdog Panthers (+5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 42.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Patriots and the Panthers have a 50% chance of covering the line.
The 42.5-point over/under is expected to go over 54% of the time.
Patriots vs Panthers: Betting Tips
- Head to Head: New England at $1.41 with Bet365
- Line: Panthers +5.5 at $1.91 with Bet365
- Total Points: Over 42.5 at $1.91 with Bet365
These Patriots vs Panthers predictions are based on world-class simulations and betting intelligence to help you place better bets with your chosen online bookie.
Patriots vs Panthers: Prediction
Stats Insider's predicted final score for Patriots vs Panthers at Gillette Stadium in Week 4 is the Patriots prevailing 24-19.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the New England vs Carolina game in Week 4, including data-driven predictions and free betting tips.
For in-depth analysis from US experts,, check out Dimers' detailed Patriots vs Panthers prediction.
18+. Odds correct at time of publishing and subject to change.Patriots vs Panthers: TD Scorer Tips
Who will score an anytime touchdown in Patriots vs Panthers? The latest data is in.
According to Stats Insider, Carolina's Chuba Hubbard is the most likely player to score the first touchdown in Patriots vs Panthers.
Hubbard has a 9.9% chance of scoring the first TD at Gillette Stadium, while the Panthers RB has a 40.3% chance of reaching the end zone at any point during the game.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Patriots First TD Tips
- Rhamondre Stevenson: 8.2% probability
- TreVeyon Henderson: 8.1% probability
- Hunter Henry: 6.8% probability
- Stefon Diggs: 5.9% probability
- Kayshon Boutte: 4.8% probability
Panthers First TD Tips
- Chuba Hubbard: 9.9% probability
- Tetairoa McMillan: 7.7% probability
- Rico Dowdle: 5.0% probability
- Hunter Renfrow: 4.3% probability
- Bryce Young: 3.2% probability
Anytime Touchdown Scorer Tips
Patriots Anytime TD Tips
- Rhamondre Stevenson: 33.2% probability
- TreVeyon Henderson: 32.8% probability
- Hunter Henry: 28.2% probability
- Stefon Diggs: 25.2% probability
- Kayshon Boutte: 21.0% probability
Panthers Anytime TD Tips
- Chuba Hubbard: 40.3% probability
- Tetairoa McMillan: 33.0% probability
- Rico Dowdle: 23.0% probability
- Hunter Renfrow: 20.1% probability
- Bryce Young: 15.1% probability
Patriots-Panthers Projected Player Stats
Of the starting quarterbacks, the Patriots' Drake Maye is projected for 221 passing yards. The Panthers' Bryce Young is expected to throw for 217 yards.
Patriots Starting QB
- Drake Maye: 221 projected passing yards
Panthers Starting QB
- Bryce Young: 217 projected passing yards
Patriots Rushing Yards
- TreVeyon Henderson: 40 projected yards
- Rhamondre Stevenson: 36 projected yards
- Drake Maye: 29 projected yards
Panthers Rushing Yards
- Chuba Hubbard: 54 projected yards
- Rico Dowdle: 26 projected yards
- Bryce Young: 18 projected yards
Patriots Receiving Yards
- Hunter Henry: 43 projected yards
- Stefon Diggs: 41 projected yards
- Kayshon Boutte: 35 projected yards
- Mack Hollins: 23 projected yards
- DeMario Douglas: 22 projected yards
Panthers Receiving Yards
- Tetairoa McMillan: 67 projected yards
- Hunter Renfrow: 35 projected yards
- Tommy Tremble: 26 projected yards
- David Moore: 24 projected yards
- Brycen Tremayne: 21 projected yards
Remember, our model updates regularly, so refresh this page for the latest betting analysis before the New England vs Carolina game.
As always, see Stats Insider's Best Bets for the best tips for every NFL game, as well as predictions for a wide range of other sports.
Patriots vs Panthers: Week 4 Essential Details
The NFL Week 4 game between the Patriots and Panthers at Gillette Stadium is scheduled to begin at 3:00am AEST on Monday.
- Teams: New England Patriots vs Carolina Panthers
- Date: Monday 29 September 2025
- Time: 3:00am AEST
- Venue: Gillette Stadium
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.
Conclusion
Our New England vs Carolina predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you decide to use our NFL predictions for betting purposes, it's important to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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