Patriots vs Bills Prediction and Preview - NFL Week 15, 2025
Last updated: Dec 8, 2025, 5:20AM | Published: Dec 7, 2025, 5:06AM
The New England Patriots will sqaure off with the Buffalo Bills in NFL Week 15 action at Gillette Stadium on Monday, starting at 5:00am AEDT.
This article features Stats Insider's free betting tips for the Patriots vs Bills game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the outcome of Monday's New England vs Buffalo NFL match-up 10,000 times.
Our proven predictive analytics model gives the Bills a 56% chance of defeating the Patriots in Week 15 of the NFL season.
Patriots vs Bills: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Gillette Stadium are listed here:
- Head to Head: Patriots $1.95, Bills $1.87
- Line: Patriots +1.5 ($1.91), Bills -1.5 ($1.91)
- Total (Over/Under 49.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Patriots at $1.95 and the Bills at $1.87.
The Patriots are 1.5-point underdogs against the Bills, with odds of $1.91 available at Bet365.
For the favourite Bills (-1.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the bookmakers have got it right and both the Patriots and the Bills have a 50% chance of covering the line.
The 49.5-point over/under is expected to stay under 56% of the time.
Patriots vs Bills: Best Bets
- Head to Head: Buffalo at $1.87 with Bet365
- Line: Bills -1.5 at $1.91 with Bet365
- Total Points: Under 49.5 at $1.91 with Bet365
When you see a 🔥, you know you've found one of Stats Insider's best tips for today across any sport.
These Patriots vs Bills best bets are based on market-leading simulations and betting expertise to help you place smarter bets with your chosen online bookie.
Patriots vs Bills: Prediction
Stats Insider's predicted final score for Patriots vs Bills at Gillette Stadium in Week 15 is the Bills winning 24-22.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the New England vs Buffalo game in Week 15, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.Remember, our model updates regularly, so bookmark this page for the latest betting predictions before the New England vs Buffalo game.
As always, see Stats Insider's Best Bets for betting tips on every NFL game, as well as predictions for a wide range of other sports.
Patriots vs Bills: Week 15 Essential Details
The NFL Week 15 match-up between the Patriots and Bills at Gillette Stadium is scheduled to commence at 5:00am AEDT on Monday.
- Teams: New England Patriots vs Buffalo Bills
- Date: Monday 15 December 2025
- Time: 5:00am AEDT
- Venue: Gillette Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our New England vs Buffalo predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's vital to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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