Panthers vs Saints Prediction and Preview - NFL Week 10, 2025
Last updated: Nov 4, 2025, 1:05PM | Published: Nov 2, 2025, 4:05AM
The Carolina Panthers will take on the New Orleans Saints in NFL Week 10 action at Bank of America Stadium on Monday, commencing at 5:00am AEDT.
This article features Stats Insider's prediction and tips for the Panthers vs Saints game, plus the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Carolina vs New Orleans NFL game 10,000 times.
Our independent predictive analytics model currently gives the Panthers a 71% chance of beating the Saints at Bank of America Stadium.
Panthers vs Saints: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Bank of America Stadium are listed below:
- Head to Head: Panthers $1.40, Saints $3.05
- Line: Panthers -5.5 ($1.91), Saints +5.5 ($1.91)
- Total (Over/Under 40 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Panthers at $1.40 and the Saints at $3.05.
The Panthers are 5.5-point favourites against the Saints, with odds of $1.91 available at Bet365.
For the underdog Saints (+5.5) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 40 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's model, the bookmakers have got it right and both the Panthers and the Saints have a 50% chance of covering the line.
The 40-point over/under is expected to go over 52% of the time.
Panthers vs Saints: Betting Tips
- Head to Head: Carolina at $1.40 with Bet365
- Line: Saints +5.5 at $1.91 with Bet365
- Total Points: Over 40 at $1.91 with Bet365
Today's Panthers vs Saints predictions are based on complex simulations and betting experience to bring you the best possible advice 24/7/365.
Panthers vs Saints: Prediction
Stats Insider's predicted final score for Panthers vs Saints at Bank of America Stadium in Week 10 is the Panthers winning 22-17.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full coverage of the Carolina vs New Orleans game in Week 10, including data-driven predictions and expert tips.
18+. Odds correct at time of publishing and subject to change.Panthers vs Saints: TD Scorer Tips
Who will score the first touchdown in Panthers vs Saints? The data is in.
According to Stats Insider, Carolina's Rico Dowdle is the most likely player to score the first TD in Panthers vs Saints.
Dowdle has a 13.1% chance of scoring the first TD at Bank of America Stadium, while the Panthers RB has a 42.8% chance of reaching the end zone at any point during the game.
Scroll down for our complete list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Panthers First TD Tips
- Rico Dowdle: 13.1% probability
- Tetairoa McMillan: 8.8% probability
- Xavier Legette: 6.0% probability
- Jalen Coker: 4.8% probability
- Bryce Young: 4.6% probability
Saints First TD Tips
- Chris Olave: 7.6% probability
- Rashid Shaheed: 7.0% probability
- Juwan Johnson: 5.7% probability
- Alvin Kamara: 5.6% probability
- Devin Neal: 4.9% probability
Anytime Touchdown Scorer Tips
Panthers Anytime TD Tips
- Rico Dowdle: 42.8% probability
- Tetairoa McMillan: 31.5% probability
- Xavier Legette: 22.7% probability
- Jalen Coker: 18.7% probability
- Bryce Young: 17.7% probability
Saints Anytime TD Tips
- Chris Olave: 35.5% probability
- Rashid Shaheed: 33.5% probability
- Juwan Johnson: 28.3% probability
- Alvin Kamara: 27.9% probability
- Devin Neal: 24.5% probability
Panthers-Saints Projected Player Stats
Of the starting quarterbacks, the Panthers' Bryce Young is projected for 216 passing yards, while the Saints' Tyler Shough is expected to throw for 212 yards.
Panthers Starting QB
- Bryce Young: 216 projected passing yards
Saints Starting QB
- Tyler Shough: 212 projected passing yards
Panthers Rushing Yards
- Rico Dowdle: 69 projected yards
- Chuba Hubbard: 23 projected yards
- Bryce Young: 13 projected yards
Saints Rushing Yards
- Alvin Kamara: 45 projected yards
- Devin Neal: 23 projected yards
- Tyler Shough: 14 projected yards
Panthers Receiving Yards
- Tetairoa McMillan: 61 projected yards
- Xavier Legette: 35 projected yards
- Jalen Coker: 32 projected yards
- Ja'Tavion Sanders: 23 projected yards
- Rico Dowdle: 20 projected yards
Saints Receiving Yards
- Chris Olave: 64 projected yards
- Rashid Shaheed: 45 projected yards
- Juwan Johnson: 36 projected yards
- Alvin Kamara: 17 projected yards
- Brandin Cooks: 15 projected yards
Remember, our model updates frequently, so refresh this page for the latest betting tips before the Carolina vs New Orleans match-up.
As always, see Stats Insider's Best Bets to get the best tips for every NFL game, as well as predictions for a wide range of other sports.
Panthers vs Saints: Week 10 Essential Details
The NFL Week 10 match-up between the Panthers and Saints at Bank of America Stadium is scheduled to commence at 5:00am AEDT on Monday.
- Teams: Carolina Panthers vs New Orleans Saints
- Date: Monday 10 November 2025
- Time: 5:00am AEDT
- Venue: Bank of America Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Carolina vs New Orleans predictions have been made after running 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.
If you choose to use our NFL predictions for betting purposes, it's crucial to gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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