Panthers vs Knights Prediction and Tips - NRL Round 12, 2025

The Panthers will sqaure off with the Knights in NRL Round 12 action at Panthers Stadium on Saturday, starting at 5:30pm AEST.

This article features Stats Insider's prediction and tips for the Panthers vs Knights game, plus the latest betting odds.

Who Will Win?

Utilising trusted machine learning and data, Stats Insider has simulated the result of Saturday's Penrith vs Newcastle NRL match 10,000 times.

Our proven predictive analytics model currently gives the Panthers an 81% chance of winning against the Knights in Round 12 of the 2025 NRL season.

Panthers vs Knights: Odds

The current Bet365 betting odds for Saturday's NRL clash at Panthers Stadium are listed below:

• Head to Head: Panthers $1.35, Knights $3.25
• Line: Panthers -8.5 ($1.91), Knights +8.5 ($1.91)
• Total (Over/Under 43.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Panthers at $1.35 and the Knights at $3.25.

The Panthers are 8.5-point favourites against the Knights, with odds of $1.91 available at Bet365.

For the underdog Knights (+8.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 43.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's analytics model, the Panthers (-8.5) are predicted to cover the line 57% of the time, while the 43.5-point over/under is expected to go over 56% of the time.

Panthers vs Knights: Best Bets

• Head to Head: Panthers at $1.35 with Bet365
• Line: Panthers -8.5 at $1.91 with Bet365
• Total Points: Over 43.5 at $1.91 with Bet365

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Our Panthers vs Knights predictions are based on detailed modelling and wagering expertise to help you place smarter bets with your chosen online bookie.

Panthers vs Knights: Prediction

Stats Insider's predicted final score for Panthers vs Knights at Panthers Stadium this Saturday is the Panthers winning 29-15.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full betting coverage of the Panthers vs Knights match on Saturday, including data-driven predictions and the best betting tips.

Our model updates regularly, so keep checking this article for the latest betting tips before the Panthers vs Knights match.

As always, see Stats Insider's Best Bets to get betting tips on every NRL match, as well as predictions for a wide range of other sports.

Panthers vs Knights: Essential Details

The NRL Round 12 clash between the Panthers and Knights at Panthers Stadium is scheduled to commence at 5:30pm AEST on Saturday.

• Teams: Penrith Panthers vs Newcastle Knights
• Date: Saturday 24 May 2025
• Kick-off: 5:30pm AEST
• Location: Panthers Stadium

All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.

Conclusion

Our Panthers vs Knights predictions have been made after running 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our rugby league tips are trustworthy and reliable, so that you can make informed decisions with confidence.

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