Panthers vs Buccaneers Prediction and Preview - NFL Week 16, 2025
Last updated: Dec 15, 2025, 9:15PM | Published: Dec 14, 2025, 5:01AM
The Carolina Panthers will face the Tampa Bay Buccaneers in NFL Week 16 action at Bank of America Stadium on Monday, starting at 5:00am AEDT.
This article features Stats Insider's prediction and tips for the Panthers vs Buccaneers game, along with the latest betting odds in Australia.
Who Will Win?
Based on trusted computer power and data, Stats Insider has simulated the result of Monday's Carolina vs Tampa Bay NFL match-up 10,000 times.
Our leading predictive analytics model gives the Buccaneers a 59% chance of beating the Panthers at Bank of America Stadium.
Panthers vs Buccaneers: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Bank of America Stadium are listed here:
- Head to Head: Panthers $2.35, Buccaneers $1.62
- Line: Panthers +3 ($1.91), Buccaneers -3 ($1.91)
- Total (Over/Under 46 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Panthers at $2.35 and the Buccaneers at $1.62.
The Panthers are listed as 3-point underdogs against the Buccaneers, with odds of $1.91 available at Bet365.
For the favourite Buccaneers (-3) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 46 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Panthers (+3) are predicted to cover the line 58% of the time, while the 46-point over/under is expected to stay under 56% of the time.
Panthers vs Buccaneers: Best Bets
- Head to Head: Carolina at $2.35 with Bet365
- Line: Panthers +3 at $1.91 with Bet365
- Total Points: Under 46 at $1.91 with Bet365
When you see a 🔥, you know you've found one of our best bets for today across any sport.
Our Panthers vs Buccaneers predictions are based on detailed modelling and wagering experience to bring you the best possible advice every day of the year.
While the Buccaneers have a higher chance of winning the game, betting on the Panthers to win is our recommended option due to the edge found when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published here at Stats Insider is pivotal to achieving long-term profitability.
Panthers vs Buccaneers: Prediction
Stats Insider's predicted final score for Panthers vs Buccaneers at Bank of America Stadium in Week 16 is the Buccaneers winning 23-21.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Carolina vs Tampa Bay game in Week 16, including data-driven predictions and free betting tips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so keep checking this article for the latest betting analysis before the Carolina vs Tampa Bay game.
As always, see our Best Bets to get the best tips on every NFL game, as well as predictions for a wide range of other sports.
Panthers vs Buccaneers: Week 16 Essential Details
The NFL Week 16 match-up between the Panthers and Buccaneers at Bank of America Stadium is scheduled to commence at 5:00am AEDT on Monday.
- Teams: Carolina Panthers vs Tampa Bay Buccaneers
- Date: Monday 22 December 2025
- Time: 5:00am AEDT
- Venue: Bank of America Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Carolina vs Tampa Bay predictions are based on 10,000 data-driven simulations of the game, all curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's crucial to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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