Panthers vs Bills Prediction and Preview - NFL Week 8, 2025
Last updated: Oct 26, 2025, 5:02PM | Published: Oct 19, 2025, 4:02AM
The Carolina Panthers will take on the favoured Buffalo Bills in NFL Week 8 action at Bank of America Stadium on Monday, starting at 4:00am AEDT.
This article features Stats Insider's free betting tips for the Panthers vs Bills game, along with the latest betting odds and touchdown scorer tips.
Who Will Win?
Utilising advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Carolina vs Buffalo NFL game 10,000 times.
Our proven predictive analytics model currently gives the Bills a 73% chance of beating the Panthers at Bank of America Stadium.
Panthers vs Bills: Odds
The current Bet365 betting odds in Australia for Monday's NFL game at Bank of America Stadium are listed here:
- Head to Head: Panthers $4.20, Bills $1.25
- Line: Panthers +7 ($1.91), Bills -7 ($1.91)
- Total (Over/Under 47.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Panthers at $4.20 and the Bills at $1.25.
The Panthers are listed as 7-point underdogs against the Bills, with odds of $1.91 available at Bet365.
For the favourite Bills (-7) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 47.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Panthers (+7) are predicted to cover the line 51% of the time, while the 47.5-point over/under is expected to is considered an equal 50-50 chance of hitting.
Panthers vs Bills: Betting Tips
- Head to Head: Carolina at $4.20 with Bet365
- Line: Panthers +7 at $1.91 with Bet365
- Total Points: Under 47.5 at $1.91 with Bet365
Today's Panthers vs Bills predictions are based on detailed modelling and wagering intelligence to help you place better bets with your chosen online bookie.
While the Bills have a higher chance of winning the game, betting on the Panthers to win is our recommended option because of the 3.6% edge identified when comparing our data-led probabilities to the odds currently available.
Taking advantage of the edges published on Stats Insider is pivotal to being a profitable sports bettor in the long run.
Panthers vs Bills: Prediction
Stats Insider's predicted final score for Panthers vs Bills at Bank of America Stadium in Week 8 is the Bills winning 26-20.
This prediction is based on each team's average score following 10,000 game simulations.
Stats Insider provides full betting coverage of the Carolina vs Buffalo game in Week 8, including data-driven predictions and live scorestips.
For in-depth analysis from US experts,, check out Dimers' detailed Panthers vs Bills prediction.
18+. Odds correct at time of publishing and subject to change.Panthers vs Bills: TD Scorer Tips
Who will score an anytime touchdown in Panthers vs Bills? The data is in.
According to Stats Insider, Buffalo's James Cook is the most likely player to score the first TD in Panthers vs Bills.
Cook has a 13.0% chance of scoring the first TD at Bank of America Stadium, while the Bills RB has a 56.7% chance of registering an anytime touchdown.
Scroll down for our full list of first touchdown scorer and anytime touchdown scorer probabilities.
First Touchdown Scorer Tips
Panthers First TD Tips
- Rico Dowdle: 7.6% probability
- Tetairoa McMillan: 7.3% probability
- Chuba Hubbard: 6.8% probability
- Xavier Legette: 4.4% probability
- Jalen Coker: 2.5% probability
Bills First TD Tips
- James Cook: 13.0% probability
- Josh Allen: 9.3% probability
- Keon Coleman: 5.1% probability
- Dalton Kincaid: 5.1% probability
- Khalil Shakir: 5.0% probability
Anytime Touchdown Scorer Tips
Panthers Anytime TD Tips
- Rico Dowdle: 33.4% probability
- Tetairoa McMillan: 32.3% probability
- Chuba Hubbard: 30.6% probability
- Xavier Legette: 20.9% probability
- Jalen Coker: 12.8% probability
Bills Anytime TD Tips
- James Cook: 56.7% probability
- Josh Allen: 45.0% probability
- Keon Coleman: 28.2% probability
- Dalton Kincaid: 27.9% probability
- Khalil Shakir: 27.3% probability
Panthers-Bills Projected Player Stats
Of the starting quarterbacks, the Panthers' Andy Dalton is projected for 222 passing yards, while the Bills' Josh Allen is expected to throw for 238 yards.
Panthers Starting QB
- Andy Dalton: 222 projected passing yards
Bills Starting QB
- Josh Allen: 238 projected passing yards
Panthers Rushing Yards
- Rico Dowdle: 56 projected yards
- Chuba Hubbard: 44 projected yards
- Andy Dalton: 7 projected yards
Bills Rushing Yards
- James Cook: 76 projected yards
- Josh Allen: 34 projected yards
- Ray Davis: 19 projected yards
Panthers Receiving Yards
- Tetairoa McMillan: 62 projected yards
- Xavier Legette: 39 projected yards
- Jalen Coker: 30 projected yards
- Ja'Tavion Sanders: 21 projected yards
- Tommy Tremble: 16 projected yards
Bills Receiving Yards
- Khalil Shakir: 53 projected yards
- Keon Coleman: 46 projected yards
- Dalton Kincaid: 43 projected yards
- Tyrell Shavers: 22 projected yards
- James Cook: 18 projected yards
Remember, our model updates frequently, so refresh this article for the latest betting predictions before the Carolina vs Buffalo match-up.
As always, see Stats Insider's Best Bets for the best tips on every NFL game, plus predictions for a wide range of other sports.
Panthers vs Bills: Week 8 Essential Details
The NFL Week 8 match-up between the Panthers and Bills at Bank of America Stadium is scheduled to begin at 4:00am AEDT on Monday.
- Teams: Carolina Panthers vs Buffalo Bills
- Date: Monday 27 October 2025
- Time: 4:00am AEDT
- Venue: Bank of America Stadium
All dates and times in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise stated.
Conclusion
Our Carolina vs Buffalo predictions are the result of 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the knowledge you need to make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's vital that you gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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