Panthers vs Bills Prediction and Preview - NFL Week 8, 2025
Last updated: Oct 19, 2025, 5:06PM | Published: Oct 19, 2025, 4:02AM
The Carolina Panthers will face the favoured Buffalo Bills in NFL Week 8 action at Bank of America Stadium on Monday, October 27, commencing at 4:00am AEDT.
This article features Stats Insider's prediction and tips for the Panthers vs Bills game, plus the latest betting odds in Australia.
Who Will Win?
Using advanced computer power and data, Stats Insider has simulated the outcome of Bills vs Panthers 10,000 times.
Our independent predictive analytics model gives the Bills a 73% chance of defeating the Panthers in Week 8 of the NFL season.
Panthers vs Bills: Odds
The current Bet365 betting odds in Australia for this NFL game at Bank of America Stadium are shown here:
- Head to Head: Panthers $4.00, Bills $1.26
- Line: Panthers +7 ($1.91), Bills -7 ($1.91)
- Total (Over/Under 48.5 Points): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, Bet365 currently has the Panthers at $4.00 and the Bills at $1.26.
The Panthers are 7-point underdogs against the Bills, with odds of $1.91 available at Bet365.
For the favourite Bills (-7) to cover the line, Bet365 offers odds of $1.91.
The over/under for total points scored is set at 48.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Panthers (+7) are predicted to cover the line 54% of the time, while the 48.5-point over/under is expected to stay under 57% of the time.
Panthers vs Bills: Best Bets
- Head to Head: Carolina at $4.00 with Bet365
- Line: Panthers +7 at $1.91 with Bet365
- Total Points: Under 48.5 at $1.91 with Bet365
If you see a 🔥, that means you've found one of Stats Insider's best tips of the day across any sport.
Our Panthers vs Bills best bets are based on market-leading modelling and wagering experience to give you the best possible advice every time.
While the Bills have a higher chance of winning the game, betting on the Panthers to win is our preferred option because of the 2.3% edge found when comparing our data-driven probabilities to the odds currently available.
Making use of the edges seen here at Stats Insider is pivotal to achieving long-term success as a sports bettor.
Panthers vs Bills: Prediction
Stats Insider's predicted final score for Panthers vs Bills at Bank of America Stadium in Week 8 is the Bills winning 26-20.
This prediction is based on each team's average score from 10,000 game simulations.
Stats Insider provides full coverage of the Carolina vs Buffalo game in Week 8, including data-driven predictions and live win probabilitiestips.
18+. Odds correct at time of publishing and subject to change.Our model updates frequently, so refresh this page for the latest betting predictions before the Carolina vs Buffalo game.
As always, see Stats Insider's Best Bets to get the best tips on every NFL game, plus predictions for a wide range of other sports.
Panthers vs Bills: Week 8 Essential Details
The NFL Week 8 match-up between the Panthers and Bills at Bank of America Stadium is scheduled to start at 4:00am AEDT on Monday, October 27.
- Teams: Carolina Panthers vs Buffalo Bills
- Date: Monday 27 October 2025
- Time: 4:00am AEDT
- Venue: Bank of America Stadium
All dates and times mentioned in this article are in Australian Eastern Daylight Time (AEDT), unless otherwise noted.
Conclusion
Our Carolina vs Buffalo predictions have been made based on 10,000 data-driven simulations of the game, carefully curated by our team of experienced data scientists and analysts. We use the latest in predictive analytics technology and machine learning to ensure our NFL tips are accurate and reliable, so that you can make informed decisions with confidence.
If you choose to use our NFL predictions for betting purposes, it's crucial to gamble responsibly and manage your finances effectively. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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