Padres vs Giants Prediction and MLB Tips - 21 August 2025
Last updated: Aug 21, 2025, 1:40AM | Published: Aug 19, 2025, 11:34PM
The San Diego Padres will take on the San Francisco Giants in MLB action at PETCO Park on Thursday, beginning at 11:40am AEST.
JP Sears (7-10, 5.12 ERA) will start on the mound for the Padres, up against Landen Roupp (7-6, 3.45 ERA) for the Giants.
This article features Stats Insider's prediction and tips for the Padres vs Giants game, along with the latest betting odds in Australia.
Who Will Win?
Utilising advanced computer power and data, Stats Insider has simulated the outcome of Thursday's San Diego vs San Francisco MLB game 10,000 times.
Our independent predictive analytics model gives the Padres a 60% chance of winning against the Giants at PETCO Park.
Padres vs Giants: Odds
The latest betting odds in Australia for Thursday's MLB game at PETCO Park are shown below:
- Head to Head: Padres $1.65, Giants $2.30
- Line: Padres -1.5 ($2.35), Giants +1.5 ($1.62)
- Total (Over/Under 8 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Padres at $1.65 and the Giants at $2.30.
The Padres are listed as 1.5-run favourites against the Giants, with odds of $2.35 available at TAB.
For the underdog Giants (+1.5) to cover the line, TAB offers odds of $1.62.
The over/under for total runs scored is set at 8 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Giants (+1.5) are predicted to cover the line 59% of the time, while the 8-run over/under is expected to stay under 52% of the time.
Padres vs Giants: Betting Tips
- Head to Head: San Diego at $1.65 with TAB
- Line: Padres -1.5 at $2.35 with TAB
- Total Runs: Under 8 at $1.91 with TAB
Stats Insider's Padres vs Giants best bets are based on market-leading simulations and gambling expertise to provide you with the best possible advice every day of the year.
Even though the Giants are more likely to cover the line, our best bet of Padres -1.5 is based on the chance of that happening, as suggested by our predictive analytics model, and the top odds available.
Padres vs Giants: Prediction
Stats Insider provides full coverage of the San Diego vs San Francisco game on Thursday, including data-driven predictions and top betting tips.
Remember, our model updates frequently, so bookmark this article for the latest betting analysis before the San Diego vs San Francisco game.
As always, see our Best Bets to get betting tips on every MLB game, as well as predictions for a wide range of other sports.
Padres vs Giants: Essential Details
The game between the Padres and Giants at PETCO Park is scheduled to begin at 11:40am AEST on Thursday.
- Teams: San Diego Padres vs San Francisco Giants
- Date: Thursday 21 August 2025
- Time: 11:40am AEST
- Venue: PETCO Park
All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our San Diego vs San Francisco predictions are based on 10,000 data-driven simulations of the game, all curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are trustworthy and reliable, so that you can make informed decisions with confidence.
If you decide to use our predictions for betting purposes, it's crucial to gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
More on MLB
Stats Insider is your home for betting on the MLB in Australia, with the latest MLB betting news, predictions for every MLB game, and futures probabilities for the MLB.
