Packers vs Lions Prediction and Preview - NFL Week 1, 2025

The Green Bay Packers will sqaure off with the Detroit Lions in NFL Week 1 action at Lambeau Field on Monday, September 8, starting at 6:25am AEST.

This article features Stats Insider's prediction and tips for the Packers vs Lions game, plus the latest betting odds in Australia.

Who Will Win?

Utilising trusted machine learning and data, Stats Insider has simulated the result of Lions vs Packers 10,000 times.

Our leading predictive analytics model currently gives the Packers a 55% chance of winning against the Lions at Lambeau Field.

Packers vs Lions: Odds

The latest Bet365 betting odds in Australia for this NFL game at Lambeau Field are shown below:

• Head to Head: Packers $1.80, Lions $2.05
• Line: Packers -1.5 ($1.91), Lions +1.5 ($1.91)
• Total (Over/Under 49.5 Points): Over $1.91, Under $1.91

Odds are correct at the time of publication and subject to change.

Looking at the latest head-to-head odds, Bet365 currently has the Packers at $1.80 and the Lions at $2.05.

The Packers are 1.5-point favourites against the Lions, with odds of $1.91 available at Bet365.

For the underdog Lions (+1.5) to cover the line, Bet365 offers odds of $1.91.

The over/under for total points scored is set at 49.5 with Bet365, which has odds of $1.91 for the over and $1.91 for the under.

According to Stats Insider's model, the bookies have got it right and both the Packers and the Lions have a 50% chance of covering the line.

The 49.5-point over/under is expected to is also considered an equal 50-50 chance of hitting.

Packers vs Lions: Best Bets

• Head to Head: Green Bay at $1.80 with Bet365
• Line: Lions +1.5 at $1.91 with Bet365
• Total Points: Under 49.5 at $1.91 with Bet365

Today's Packers vs Lions best bets are based on market-leading modelling and gambling experience to give you the best possible advice every day of the year.

Packers vs Lions: Prediction

Stats Insider's predicted final score for Packers vs Lions at Lambeau Field in Week 1 is the Packers winning 25-24.

This prediction is based on each team's average score from 10,000 game simulations.

Stats Insider provides full coverage of the Green Bay vs Detroit game in Week 1, including data-driven predictions and free betting tips.

Remember, our model updates regularly, so refresh this article for the latest betting analysis before the Green Bay vs Detroit game.

As always, see our Best Bets for betting tips on every NFL game, as well as predictions for a wide range of other sports.

Packers vs Lions: Week 1 Essential Details

The NFL Week 1 match-up between the Packers and Lions at Lambeau Field is scheduled to start at 6:25am AEST on Monday, September 8.

• Teams: Green Bay Packers vs Detroit Lions
• Date: Monday 8 September 2025
• Time: 6:25am AEST
• Venue: Lambeau Field

All dates and times mentioned in this article are in Australian Eastern Standard Time (AEST), unless otherwise stated.

Conclusion

Our Green Bay vs Detroit predictions have been made thanks to 10,000 data-driven simulations of the game, carefully curated by our team of expert data scientists and analysts. We use cutting-edge technology and machine learning to ensure our NFL tips are trustworthy and reliable, giving you the confidence to make informed decisions.

If you choose to use our NFL predictions for betting purposes, it's crucial that you gamble responsibly and keep track of your money. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.

More on NFL

Stats Insider is your home for betting on the NFL in Australia, with the latest NFL betting news, tips for every NFL game, and Super Bowl probabilities for the NFL.