Orioles vs Yankees Prediction and MLB Tips - 22 September 2025
Last updated: Sep 21, 2025, 5:36PM | Published: Sep 20, 2025, 6:30PM
The Baltimore Orioles will take on the New York Yankees in Game of the League Series at Oriole Park at Camden Yards on Monday, commencing at 3:35am AEST.
The Orioles will have Kyle Bradish (1-1, 2.46 ERA) start, while the Yankees are going with Cam Schlittler (3-3, 3.41 ERA).
This article features Stats Insider's prediction and tips for the Orioles vs Yankees game, plus the latest betting odds in Australia.
Who Will Win?
Based on advanced machine learning and data, Stats Insider has simulated the outcome of Monday's Baltimore vs NY Yankees MLB game 10,000 times.
Our leading predictive analytics model currently gives the Yankees a 53% chance of winning against the Orioles at Oriole Park at Camden Yards.
Orioles vs Yankees: Odds
The current betting odds in Australia for Monday's MLB game at Oriole Park at Camden Yards are shown here:
- Head to Head: Orioles $2.10, Yankees $1.77
- Line: Orioles +1.5 ($1.67), Yankees -1.5 ($2.25)
- Total (Over/Under 8.5 Runs): Over $1.91, Under $1.91
Odds are correct at the time of publication and subject to change.
Looking at the latest head-to-head odds, the bookmakers currently have the Orioles at $2.10 and the Yankees at $1.77.
The Orioles are listed as 1.5-run underdogs against the Yankees, with odds of $1.67 available at TAB.
For the favourite Yankees (-1.5) to cover the line, TAB offers odds of $2.25.
The over/under for total runs scored is set at 8.5 with TAB, which has odds of $1.91 for the over and $1.91 for the under.
According to Stats Insider's analytics model, the Orioles (+1.5) are predicted to cover the line 58% of the time, while the 8.5-run over/under is expected to go over 52% of the time.
Orioles vs Yankees: Betting Tips
- Head to Head: Baltimore at $2.10 with TAB
- Line: Orioles +1.5 at $1.67 with TAB
- Total Runs: Over 8.5 at $1.91 with TAB
Stats Insider's Orioles vs Yankees best bets are based on complex simulations and wagering experience to bring you the best possible advice every day of the year.
While the Yankees have a higher chance of winning the game, betting on the Orioles to win is our preferred option due to the edge identified when comparing our data-led probabilities to the odds currently on offer.
Making use of the edges published on Stats Insider is one of the keys to being profitable in the long run.
Orioles vs Yankees: Prediction
Stats Insider provides full coverage of the Baltimore vs NY Yankees game on Monday, including data-driven predictions and live win probabilitiestips.
Remember, our model updates regularly, so refresh this page for the latest betting predictions before the Baltimore vs NY Yankees match-up.
As always, see our Best Bets for betting tips on every MLB game, as well as predictions for a wide range of other sports.
Orioles vs Yankees: Essential Details
The match-up between the Orioles and Yankees at Oriole Park at Camden Yards is scheduled to start at 3:35am AEST on Monday.
- Teams: Baltimore Orioles vs New York Yankees
- Date: Monday 22 September 2025
- Time: 3:35am AEST
- Venue: Oriole Park at Camden Yards
All dates and times in this article are in Australian Eastern Standard Time (AEST), unless otherwise noted.
Conclusion
Our Baltimore vs NY Yankees predictions have been made thanks to 10,000 data-driven simulations of the game, all curated by our team of skilled data scientists and analysts. We use cutting-edge technology and machine learning to ensure our MLB tips are accurate and reliable, so that you can make informed decisions with confidence.
If you decide to use our MLB predictions for betting purposes, it's crucial that you gamble responsibly and know when to stop. For free and confidential support, call 1800 858 858 or visit gamblinghelponline.org.au.
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